4-Fluorobenzylamine Chemical Properties

Melting point:

183 °C

Boiling point:

183 °C (lit.)

Density 

1.095 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.512(lit.)

Flash point:

152 °F

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

pka

9.01±0.10(Predicted)

form 

Liquid

Specific Gravity

1.101.095

color 

Clear colorless to light yellow

Water Solubility 

Soluble in water.

Sensitive 

Air Sensitive

BRN 

636501

InChIKey

IIFVWLUQBAIPMJ-UHFFFAOYSA-N

CAS DataBase Reference

140-75-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzenemethanamine, 4-fluoro-(140-75-0)

EPA Substance Registry System

Benzenemethanamine, 4-fluoro- (140-75-0)

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

34-20/21/22

Safety Statements 

26-27-36/37/39-45-36/39

RIDADR 

UN 2735 8/PG 2

WGK Germany 

3

F 

10-34

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29214980

MSDS

• Language:English Provider:4-Fluorobenzylamine
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4-Fluorobenzylamine Usage And Synthesis

Chemical Properties

Colorless to light yellow liquid.

Uses

4-Fluorobenzylamine is used as a potassium channel blocking agent. It is used in the synthesis of new tris-iron(III) chelates of 3-hydroxy-4-pyridinone ligands. It reacts with the α- and γ-carboxyl groups of folic acid to yield 18F-labeled folate2. It is an important building block for the synthesis of 18F-labeled compounds.

General Description

[¹⁸F]4-fluorobenzylamine reacts with the α- and γ-carboxyl groups of folic acid to yield ¹⁸F-labeled folate. It is an important building block for the synthesis of ¹⁸F-labeled compounds.

Synthesis

In a 100ml reaction flask, add 25.5g (0.1mol) of N-(4-fluorobenzyl)phthalimide and 25ml of absolute ethanol, then add 6.3g (0.1mol) of 80% hydrazine hydrate solution, and heat Reflux 0.5g. Excessive hydrochloric acid was added to decompose the precipitated white precipitate, after cooling, an appropriate amount of water was added to stir, and suction filtered. The filtrate was neutralized with NaOH solution, extracted with ether, and the ether extract was dried, evaporated to remove ether, distilled under reduced pressure, and collected fractions at 44-46°C (67kPa) to obtain 7.1 g of 4-fluorobenzylamine, with a yield of 56.5%.

4-Fluorobenzylamine(140-75-0)Related Product Information

• 4-Fluorobenzamide
• Trimethoprim
• Methylamine hydrochloride
• Meglumine
• Ethyl nicotinate
• Phenoxybenzamine hydrochloride
• Trimethylamine
• N-Methylbenzylamine
• 4-Fluorobenzoic acid
• Dibenzylamine
• Benzylamine
• 2,4-Difluorobenzylamine
• 4-Fluorothiophenol
• 4-Fluoromandelic acid
• Methyl 4-fluorobenzoate
• Ethyl 4-fluorobenzoate
• 4-Fluorobenzonitrile
• 4-Fluorobenzaldehyde