3,4-D Chemical Properties

Melting point:

138-140 °C(lit.)

Boiling point:

316.96°C (rough estimate)

Density 

1.4564 (rough estimate)

refractive index 

1.5000 (estimate)

Flash point:

2 °C

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

2.99±0.10(Predicted)

color 

White

Water Solubility 

457.6mg/L(25 ºC)

Safety Information

Hazard Codes 

Xi,Xn,F

Risk Statements 

36/37/38-36-20/21/22-11

Safety Statements 

26-37/39-36-16

RIDADR 

2811

WGK Germany 

3

RTECS 

AG6830000

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

2918999090

MSDS

• Language:English Provider:SigmaAldrich

3,4-D Usage And Synthesis

Uses

3,4-Dichlorophenoxyacetic acid was used in the synthesis of layered organic-inorganic nanohybrid material, zinc-aluminum-3,4-dicholorophenoxyacetate.

Definition

ChEBI: A chlorophenoxyacetic acid that is phenoxyacetic acid in which the hydrogens at positions 3 and 4 of the phenyl group are replaced by chlorines.

General Description

3,4-Dichlorophenoxyacetic acid is a phenoxyacetic herbicide.

Synthesis

GENERAL PROCEDURE: To a stirred solution of 4j (2.5 g, 9.8 mmol) in methanol (30 mL) was added 3N sodium hydroxide solution (13.1 mL, 39.3 mmol). After stirring for 1 h at room temperature, the reaction mixture was diluted with water (100 mL), acidified with 3N hydrochloric acid to pH < 7, and subsequently extracted with dichloromethane (100 mL x 2). The organic layers were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 3,4-dichlorophenoxyacetic acid (2.12 g, 97% yield) as a white solid. The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 7.49 (d, J=8.8 Hz, 1H), 7.21 (s, 1H), 6.92 (d, J=8.8 Hz, 1H), 4.73 (s, 2H).

References

[1] Bulletin of the Korean Chemical Society, 2015, vol. 36, # 10, p. 2549 - 2552
[2] Patent: WO2017/212423, 2017, A1. Location in patent: Page/Page column 97; 98

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