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1-Methyl L-aspartate

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1-Methyl L-aspartate Basic information

Product Name:
1-Methyl L-aspartate
Synonyms:
  • L-ASPARTIC ACID ALPHA-METHYL ESTER
  • ASPARTIC ACID-OME
  • H-ASP-OME
  • L-ASPARTIC ACID-1-METHYL ESTER
  • ASP(OMe)
  • Aspartic acid 1-methyl ester
  • L-3-Amino-3-(methoxycarbonyl)propionic acid
  • L-Aspartic acid hydrogen 1-methyl ester
CAS:
17812-32-7
MF:
C5H9NO4
MW:
147.13
Product Categories:
  • Aspartic acid [Asp, D]
  • Amino Acids and Derivatives
  • Amino Acid Methyl Esters
  • Amino Acids
  • Amino Acids (C-Protected)
  • Biochemistry
  • Amino Acids Derivatives
Mol File:
17812-32-7.mol
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1-Methyl L-aspartate Chemical Properties

Melting point:
186 °C
Boiling point:
272.7±30.0 °C(Predicted)
Density 
1.299±0.06 g/cm3(Predicted)
refractive index 
36 ° (C=0.5, H2O)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Soluble in water
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
3.45±0.19(Predicted)
form 
Powder
color 
White
optical activity
Consistent with structure
CAS DataBase Reference
17812-32-7(CAS DataBase Reference)
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Safety Information

HS Code 
2922.49.8000
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1-Methyl L-aspartate Usage And Synthesis

Uses

Aspartic Acid α-Methyl Ester is a derivative of L-Aspartic Acid, a non-essential amino acid found in food sources and dietary supplements. L-Aspartic Acid is one of the 20 proteinogenic amino acids; t he building blocks of proteins. Its conjugate base L-aspartate is an excitatory neurotransmitter in the central nervous system.

Synthesis

60504-59-8

17812-32-7

Example 2: 1.75 g of N-formyl-L-aspartic acid α-methyl ester (10 mmol) was dissolved with 3.5 g of hydroxylamine hydrochloride (50 mmol) in 10 mL of 90% methanol solution. The reaction mixture was stirred at 70 °C for 4 hours. Upon completion of the reaction, the reaction mixture was analyzed and confirmed to contain L-aspartic acid α-methyl ester in 85% yield.

References

[1] Patent: US4021418, 1977, A

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