2-Quinolinol Chemical Properties

Melting point:

198-199 °C (lit.)

Boiling point:

264.27°C (rough estimate)

Density 

1.1555 (rough estimate)

refractive index 

1.4500 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

alcohol: soluble(lit.)

form 

Powder

pka

-0.31, 11.76(at 20℃)

color 

White to light purple or purple-brownish

Water Solubility 

1.052g/L(20 ºC)

Merck 

14,1825

BRN 

2855

CAS DataBase Reference

59-31-4(CAS DataBase Reference)

NIST Chemistry Reference

2(1H)-Quinolinone(59-31-4)

EPA Substance Registry System

2(1H)-Quinolinone (59-31-4)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-20/21/22-41-37/38-22

Safety Statements 

26-37/39-36

RIDADR 

2811

WGK Germany 

3

RTECS 

FG7175000

Hazard Note 

Harmful/Irritant

TSCA 

Yes

HS Code 

29334900

MSDS

• Language:English Provider:Carbostyril
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Quinolinol Usage And Synthesis

Chemical Properties

white to light purple or purple-brownish powder

Uses

2-Hydroxyquinoline was used to obtain the design of the platinum(IV) complexes with intense bands shifted towards longer wavelengths. The Pt(IV) complexes are inert stable prodrugs that were photoactivated to produce Pt(II) species with promising anticancer activity.

Definition

ChEBI: A quinolone that is 1,2-dihydroquinoline substituted by an oxo group at position 2.

Synthesis Reference(s)

Synthesis, p. 739, 1975 DOI: 10.1055/s-1975-23918

General Description

2-Hydroxyquinoline is a specific inhibitor of plaque paraoxonase1 (PON1).

Purification Methods

Crystallise it from MeOH. It has m 200-201o after sublimation in a vacuum. The picrate has m 132o after crystallisation from Et2O. [Gibson et al. J Chem Soc 4340 1955, Beilstein 21 III/IV 1057, 21/8 V 217.]

2-Quinolinol(59-31-4)Related Product Information

• 6-Hydroxyquinoline
• 8-Hydroxyquinoline
• Quinhydrone
• 4-Hydroxyquinoline
• 4-HYDROXY-1-METHYL-2-QUINOLONE
• 2-Hydroxy-4-quinolincarboxylic acid
• 2,8-Quinolinediol
• 1-METHYL-2-QUINOLINONE
• 2-HYDROXY-4-METHYLQUINOLINE
• Cinchocaine
• 2,4-QUINOLINEDIOL
• 6-BROMO-2-HYDROXYQUINOLINE-4-CARBOXYLIC ACID
• 6-bromo-3-methyl-3H-dibenz[f,ij]isoquinoline-2,7-dione
• 2,4-DIHYDROXYQUINOLINE MONOSODIUM SALT
• 4-Bromomethyl-1,2-dihydroquinoline-2-one
• 1,2,3,4-TETRAHYDRO-8-HYDROXYQUINOLINE,1,2,3,4-TETRAHYDRO-8-QUINOLINOL
• 4-AMINOCINNAMIC ACID
• Dibucaine hydrochloride