Phthalazine Chemical Properties

Melting point:

89-92 °C(lit.)

Boiling point:

189 °C29 mm Hg(lit.)

Density 

1.1509 (rough estimate)

refractive index 

1.6231 (estimate)

Flash point:

178-180°C/15mm

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

3.47(at 20℃)

color 

Slightly brown to beige

Water Solubility 

Soluble in water, methanol, chloroform.

Merck 

14,7370

BRN 

109240

CAS DataBase Reference

253-52-1(CAS DataBase Reference)

NIST Chemistry Reference

Phthalazine(253-52-1)

EPA Substance Registry System

Phthalazine (253-52-1)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-68

Safety Statements 

24/25-37/39-36-26-36/37/39

WGK Germany 

3

TSCA 

Yes

HS Code 

29339900

MSDS

• Language:English Provider:2,3-Benzodiazine
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Phthalazine Usage And Synthesis

Chemical Properties

SLIGHTLY BROWN TO BEIGE CRYSTALLINE POWDER

Uses

Phthalazine derivatives including copper and platinum complexes were induce the apoptosis in breast cancer cell lines and renal hyperemia.

Uses

Phthalazine is a heterocyclic organic compound isomeric with quinoxaline, cinnoline and quinazoline. Aminophthalazine compounds serve as effective phosphodiesterase (PDE) inhibitors.

Definition

ChEBI: Phthalazine is an azaarene that is the 2,3-diaza analogue of naphthalene. The parent of the class of phthalazines. It is a mancude organic heterobicyclic parent, a member of phthalazines, an azaarene and an ortho-fused heteroarene.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 2, p. 206, 1965 DOI: 10.1002/jhet.5570020219

Purification Methods

Phthalazine crystallises from diethyl ether or *benzene, and sublimes under a vacuum. The hydrochloride forms needles from EtOH with m 235-236o(dec) and the picrate has m 208-210o. [Armarego J Appl Chem 11 70 1961, Beilstein 23 H 174, 23 III/IV 1233.]

Phthalazine(253-52-1)Related Product Information

• DBU
• Phthalylsulfathiazole
• Phthalhydrazide
• Phthalic anhydride
• Phthaloyl amlodipine
• Ophthazin
• Todralazine hydrochloride
• (DHQ)2PHAL
• 1,4-Dichlorophthalazine
• 1-BENZYL-4-CHLOROPHTHALAZINE
• 1-CHLOROPHTHALAZINE
• Dihydralazine sulphate
• 1-(2-(1,3-DIMETHYL-2-BUTENYLIDENE)HYDRAZINO)PHTHALAZINE
• METHYL 2-[(4-BENZYL-1-PHTHALAZINYL)SULFANYL]ACETATE
• Phthalazine
• 1-BENZYL-4-[(4-CHLOROBENZYL)SULFANYL]PHTHALAZINE
• 1-BENZYL-4-(4-METHOXYPHENOXY)PHTHALAZINE
• 4-[(4-BENZYL-1-PHTHALAZINYL)OXY]BENZENECARBONITRILE