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GABAPENTIN-D6 HYDROCHLORIDE

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GABAPENTIN-D6 HYDROCHLORIDE Basic information

Product Name:
GABAPENTIN-D6 HYDROCHLORIDE
Synonyms:
  • GABAPENTIN-D6 HYDROCHLORIDE
  • 1-(aminomethyl)cyclohexaneacetic acid hydrochloride
  • Neurontin hydrochloride
  • 2-(1-(aminomethyl)cyclohexyl)acetic acid hydrochloride
  • Cyclohexaneacetic acid, 1-(aminomethyl)-, hydrochloride (1:1)
  • Neurontin HCl
  • 1-(Amino Methyl) Cyclohexane Acetic Acid Hydrochloride Hemihydrate Salt
  • 1-AMINOMETHYL CYCLOHEXANACTIC ACID HYDROCHLORIDE
CAS:
60142-95-2
MF:
C9H12ClD6NO2
MW:
213.73
EINECS:
262-075-8
Product Categories:
  • Inhibitors
Mol File:
Mol File
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GABAPENTIN-D6 HYDROCHLORIDE Chemical Properties

Melting point:
148-151℃ (ethanol )
Density 
0.001g/cm3 at 20℃
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Off-White
LogP
-1.33--1.17 at pH4-9
Surface tension
63.69mN/m at 1g/L and 20℃
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GABAPENTIN-D6 HYDROCHLORIDE Usage And Synthesis

Uses

Gabapentin Hydrochloride is a salt analogue of Gabapentin-d6 (G117253), a labelled amino acid structurally related to γ-Aminobutyric Acid (GABA), designed to cross the blood brain barrier. Used as an anticonvulsant.

Biological Activity

gabapentin (neurontin) is a pharmaceutical drug, specifically a gaba analog. it was originally developed to treatepilepsy, and currently is also used to relieve neuropathic pain.

in vivo

Gabapentin (5 and 10 mg/kg; i.p.; once; male BALB/c mice) hydrochloride has improving effects on spatial and emotional cognitive performance of naive mice in Morris water maze (MWM), passive avoidance (PA) and modified elevated plus maze (mEPM) tasks[2].
Gabapentin (1-100 mg/kg; i.p.; once; male mice) hydrochloride has analgesic effect and reduces writhing in a dose-dependent manner[3].

Animal Model:Male BALB/c mice (35-45 g)[2]
Dosage:5 and 10 mg/kg
Administration:Intraperitoneal injection; once
Result:Increased the time spent in target quadrant and decreased the distance to platform in MWM test
. Decreased the transfer latency on second day in mEPM test
. Prolonged retention latency in PA test
.
Animal Model:Male mice (26-30 g)[3]
Dosage:1, 5, 10, 50 and 100 mg/kg
Administration:Intraperitoneal injection; once
Result:Produced 45-70% inhibition of writhing.

GABAPENTIN-D6 HYDROCHLORIDESupplier

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