Hexadecyl trimethyl ammonium bromide Chemical Properties

Melting point:

248-251 °C(lit.)

Density 

1.1107 (rough estimate)

refractive index 

1.5260 (estimate)

Flash point:

244 °C

storage temp. 

Store below +30°C.

solubility 

H₂O: 50 mg/mL

form 

powder

color 

white

PH

5.0-7.0 (25℃, 0.1M in H2O)

Odor

Odorless

PH Range

5 - 7

Water Solubility 

13 g/L (20 ºC)

Sensitive 

Hygroscopic

λmax

λ: 260 nm Amax: 0.06
λ: 280 nm Amax: 0.05

Merck 

14,2025

BRN 

3598189

Stability:

Stable. Incompatible with strong oxidizing agents. Protect from moisture.

InChIKey

LZZYPRNAOMGNLH-UHFFFAOYSA-M

CAS DataBase Reference

57-09-0(CAS DataBase Reference)

EPA Substance Registry System

Cetyl trimethyl ammonium bromide (57-09-0)

Safety Information

Hazard Codes 

Xn,N

Risk Statements 

22-37/38-41-50-50/53-36/37/38-48/22

Safety Statements 

26-39-61-37/39-60-36

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

RTECS 

BQ7875000

F 

3

TSCA 

Yes

HazardClass 

9

PackingGroup 

III

HS Code 

29239000

Toxicity

LD50 in mice, rats (mg/kg): 32.0, 44.0 i.v. (Isomaa, Bjondahl)

MSDS

• Language:English Provider:Hexadecyl trimethyl ammonium bromide
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Hexadecyl trimethyl ammonium bromide Usage And Synthesis

Chemical Properties

White powder. Soluble in water, alcohol, and chloroform.

Uses

Hexadecyltrimethylammonium Bromide (CTAB) is a cationic surfactant used as a template in the synthesis of Mesoporous γ-Fe2O3.

Uses

cetrimonium bromide is a quaternary ammonium salt that can prevent the proliferation of bacteria, fungi, and yeast in cosmetic preparation, while also act as an emulsifying agent.

Uses

antiinfectant

Uses

A cationic detergent used in the isolation of high molecular weight DNA.

Definition

ChEBI: The organic bromide salt that is the bromide salt of cetyltrimethylammonium; one of the components of the topical antiseptic cetrimide.

General Description

Hexadecyltrimethylammonium bromide is a titrant for the potentiometric titration of perchlorate with ionselective electrodes.

Biochem/physiol Actions

Hexadecyltrimethylammonium bromide also called cetyltrimethylammonium bromide (CTAB), is a cationic surfactant. CTAB is employed for extraction of DNA. CTAB method is efficient, cost and time effective for DNA extraction. CTAB is used as a shaping material and reducing agent for nanoparticle generation.

Purification Methods

Crystallise it from EtOH, EtOH/*benzene or from wet acetone after extracting twice with pet ether. Shake it with anhydrous diethyl ether, filter and dissolve it in a little hot MeOH. After cooling in the refrigerator, the precipitate is filtered off at room temperature and re-dissolved in MeOH. Anhydrous ether is added and, after warming to obtain a clear solution, it is cooled and the crystalline material is collected. [Dearden & Wooley J Phys Chem 91 2404 1987, Hakemi et al. J Am Chem Soc 91 120 1987, Beilstein 4 IV 819.]

References

[1] Liu, Tingting et al. “Hexadecyl trimethyl ammonium bromide assisted growth of NiCo2O4@reduced graphene oxide/ nickel foam nanoneedle arrays with enhanced performance for supercapacitor electrodes?.” RSC Advances 7 (2022): 4029–4041.

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