PTIO Chemical Properties

Melting point:

approximate 86℃

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

Dark blue solid

color 

Blue to Dark blue

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

2933.99.8210

MSDS

• Language:English Provider:SigmaAldrich

PTIO Usage And Synthesis

Description

PTIO is an oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. It can be used to assay nitric oxide production when examining nitric oxide synthase inhibitory activity.

Chemical Properties

blue crystals

Uses

PTIO is a nitric oxide (NO) radical scavenger used to inhibit physiological effects of NO.

Uses

2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.

Synthesis Reference(s)

Journal of the American Chemical Society, 90, p. 1078, 1968 DOI: 10.1021/ja01006a053

General Description

Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors.

Biochem/physiol Actions

Product does not compete with ATP.

PTIO(18390-00-6)Related Product Information

• Oxazoline
• 2-Phenyl-2-imidazoline
• PTIO
• 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, NA
• 2-(4-NITROPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL
• 3,3,4,4-TETRAMETHYL-2-TRIMETHYLAMMONIOPHENYL-2-IMIDAZOLINE-3-OXIDE-1-YLOXY CHLORIDE
• 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide
• CARBOXY-PTIO
• 1H-IMIDAZOL-1-YLOXY, 2-(1,3-BENZODIOXOL-5-YL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-, 3-OXIDE