PTIO
PTIO Basic information
- Product Name:
- PTIO
- Synonyms:
-
- 2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl)[stablefreeradicalreagentforthesimultaneousdetermin
- 2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE
- 2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL
- PTIO
- PTIO (2-PHENYL-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL)
- PTIO (=2-Phenyl-4,4,5,5-tetramethylimidazoline-3-oxide-1-oxyl) [Stable free radical reagent for the simultaneous determination of NO and NO2 in the atmosphere]
- [(2-Phenyl-4,4,5,5-tetramethyl-3-oxylato-4,5-dihydro-1H-imidazole-3-ium)-1-yloxy]radical
- [(4,5-Dihydro-2-phenyl-4,4,5,5-tetramethyl-1H-imidazole-3-oxide)-1-yloxy]radical
- CAS:
- 18390-00-6
- MF:
- C13H17N2O2
- MW:
- 233.29
- Mol File:
- 18390-00-6.mol
PTIO Chemical Properties
- Melting point:
- approximate 86℃
- storage temp.
- 2-8°C
- solubility
- soluble in Methanol
- form
- Dark blue solid
- color
- Blue to Dark blue
- InChI
- InChI=1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3
- InChIKey
- DYUUGILMVYJEHY-UHFFFAOYSA-N
- SMILES
- C1(C)(C)N([O])C(C2C=CC=CC=2)=[N+]([O-])C1(C)C |^1:4|
MSDS
- Language:English Provider:SigmaAldrich
PTIO Usage And Synthesis
Description
PTIO is an oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides. It can be used to assay nitric oxide production when examining nitric oxide synthase inhibitory activity.
Chemical Properties
blue crystals
Uses
PTIO is a nitric oxide (NO) radical scavenger used to inhibit physiological effects of NO.
Uses
2-phenyl-4, 4, 5, 5,-tetramethylimidazoline-1-oxyl 3-oxide (PTIO) has been used as a nitric oxide (NO) scavenger.
Synthesis Reference(s)
Journal of the American Chemical Society, 90, p. 1078, 1968 DOI: 10.1021/ja01006a053
General Description
Nitric oxide radical scavenger. Reacts with nitric oxide in a stoichiometric manner without affecting nitric oxide synthase activity. Inhibits the enhanced vascular permeability in solid tumors.
Biochem/physiol Actions
Product does not compete with ATP.
References
[1] SARA GOLDSTEIN Amram S Angelo Russo. Reactions of PTIO and carboxy-PTIO with *NO, *NO2, and O2-*.[J]. The Journal of Biological Chemistry, 2003, 278 51: 50949-50955. DOI: 10.1074/jbc.m308317200
[2] N NAKATSUBO. Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors.[J]. Biological & pharmaceutical bulletin, 1998, 21 12: 1247-1250. DOI: 10.1248/bpb.21.1247
PTIOSupplier
- Tel
- 15121041756
- xingui2022@126.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 4006356688 18621169109
- market03@meryer.com
- Tel
- 021-67121386
- Sales-CN@TCIchemicals.com
- Tel
- 021-021-58432009 400-005-6266
- sales8178@energy-chemical.com
PTIO(18390-00-6)Related Product Information
- Oxazoline
- 2-Phenyl-2-imidazoline
- PTIO
- 2-(4-CARBOXYPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-1-OXYL-3-OXIDE, NA
- 2-(4-NITROPHENYL)-4,4,5,5-TETRAMETHYLIMIDAZOLINE-3-OXIDE-1-OXYL
- 3,3,4,4-TETRAMETHYL-2-TRIMETHYLAMMONIOPHENYL-2-IMIDAZOLINE-3-OXIDE-1-YLOXY CHLORIDE
- 2-(4-Carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide
- CARBOXY-PTIO
- 1H-IMIDAZOL-1-YLOXY, 2-(1,3-BENZODIOXOL-5-YL)-4,5-DIHYDRO-4,4,5,5-TETRAMETHYL-, 3-OXIDE