Dithizone Chemical Properties

Melting point:

168 °C (dec.) (lit.)

Boiling point:

376.1±25.0 °C(Predicted)

Density 

1.2578 (rough estimate)

refractive index 

1.5700 (estimate)

storage temp. 

no restrictions.

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Crystalline

pka

pK1:4.50;pK2:15 (25°C)

color 

Black powder

Water Solubility 

Soluble in ethanol, chloroform, dimethylsulfoxide, and pyridine. Insoluble in water.

Merck 

14,3377

BRN 

748838

Stability:

Stable. Incompatible with strong oxidizing agents.

CAS DataBase Reference

60-10-6(CAS DataBase Reference)

EPA Substance Registry System

Diazenecarbothioic acid, phenyl-, 2-phenylhydrazide (60-10-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

22-36/37/38

Safety Statements 

36-26

RIDADR 

2811

WGK Germany 

3

RTECS 

LQ9450000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29309090

MSDS

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Dithizone Usage And Synthesis

Chemical Properties

dark brown or black crystals

Uses

Dithizone is an organosulfur compound that acts as a chelating agent and forms complexes with metals such as lead and mercury. Dithizone is used to assess the purity of human pancreatic islet preparations used for transplantation into patients with type 1 diabetes.

Uses

Dithizone is used as an indicator for minute amounts of lead. It acts as a chelating agent for heavy metal poisoning. As a ligand, it forms complexes with metals like zinc, lead and mercury. Further, it is used to assess the purity of human pancreatic islet preparations, which is used for transplantation in patients with type 1 diabetes. In addition to this, it is used as a titrant in the quantitative determination of heavy metals.

Uses

Sensitive reagent for several heavy metals, Co, Cu, Pb, and Hg; especially for the estimation of minute amounts of Pb.

Definition

ChEBI: Dithizone is a member of phenylhydrazines.

General Description

Dithizone (Diphenylthiocarbazone) is used as chelating agent for zinc. It is widely used for the liquid-liquid and solid phase extraction of various metals since it forms stable complexes with the metals.

Purification Methods

The crude dithizone is dissolved in CCl4 to give a concentrated solution. This is filtered through a sintered glass funnel and shaken with 0.8M aqueous ammonia to extract dithizonate ion. The aqueous layer is washed with several portions of CCl4 to remove undesirable materials. The aqueous layer is acidified with dilute H2SO4 to precipitate pure dithizone. This is dried in a vacuum. When only small amounts of dithizone are required, purification by paper chromatography is convenient. [Cooper & Hibbits J Am Chem Soc 75 5084 1933.] Instead of CCl4, CHCl3 can be used, and the final extract, after washing with water, can be evaporated in air at 40-50o and dried in a desiccator. It complexes with Cd, Hg, Ni and Zn. [Beilstein 16 H 26, 16 IV 18.]

Dithizone(60-10-6)Related Product Information

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• Dithizone