(+)-PHYLLODULCIN Chemical Properties

form 

Solid

color 

White to off-white

(+)-PHYLLODULCIN Usage And Synthesis

Uses

Phyllodulcin is an orally active sweetener found in Hydrangea macrophylla var. thunbergii. Phyllodulcin acts as a non-selective phosphodiesterase inhibitor and exerts anti-allergic effects by suppressing lymphocyte activation. Phyllodulcin can be used to combat obesity by regulating levels of leptin, fat browning-related genes, and hypothalamic BDNF-TrkB signaling[1][2].

Definition

ChEBI: Phyllodulcin is a hydroxybenzoic acid.

References

[1] Liu J, et al. Medicinal flowers. XXXX . Structures of dihydroisocoumarin glycosides and inhibitory effects on aldose reducatase from the flowers of Hydrangea macrophylla var.thunbergii. Chem Pharm Bull (Tokyo). 2013;61(6):655-61. DOI:10.1248/cpb.c13-00160
[2] Kim E, et al. Phyllodulcin, a Natural Sweetener, Regulates Obesity-Related Metabolic Changes and Fat Browning-Related Genes of Subcutaneous White Adipose Tissue in High-Fat Diet-Induced Obese Mice. Nutrients. 2017 Sep 21;9(10):1049. DOI:10.3390/nu9101049

(+)-PHYLLODULCIN(21499-23-0)Related Product Information

• Bletillae Rhizoma
• lycii Fructus
• Psoralen
• Angelicae Sinensis Radix
• Vaccariae Semen
• Ophiopogonis Radix
• RADIX SCUTELLARIAE
• Forsythiae Fructus
• Benzyl salicylate
• Isopropyl salicylate
• 2-Bibenzylcarboxylic acid
• 3,4-dihydro-1H-2-benzopyran-1-one
• (+)-PHYLLODULCIN
• hydrangenol
• 6-METHYLSALICYLIC ACID ETHYL ESTER
• 1H-2-BENZOPYRAN-1-ONE, 3,4-DIHYDRO-8-HYDROXY-
• 3-PHENYL-3,4-DIHYDROISOCOUMARIN