NF449
NF449 Basic information
- Product Name:
- NF449
- Synonyms:
-
- 4,4',4'',4'''-[CARBONYLBIS(IMINO-5,1,3-BENZENETRIYL-BIS(CARBONYLIMINO))]TETRAKIS-1,3-BENZENEDISULFONIC ACID, OCTASODIUM SALT
- 4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYL-IMINO)]]TETRAKIS(BENZENE-1,3-DISULFONIC ACID) OCTASODIUM SALT
- 4,4',4'',4'''-[CARBONYL-BIS[IMINO-5,1,3-BENZENETRIYL BIS-(CARBONYLIMINO)]]TETRAKIS-(BENZENE-1,3-DISULFONIC ACID, 8NA)
- NF449
- NF449 OCTASODIUM SALT
- 4,4',4'',4'''-(Carbonylbis(imino-5,1,3-benzenetriyl-bis(carbonylimino)))tetrakis-1,3-benzenedisulfonicacid,octasodium
- 4,4μ,4,4μ-[Carbonylbis[imino-5,1,3-benzenetriyl bis(carbonyl-imino)]]tetrakis(benzene-1,3-disulfonic acid) octasodium salt
- NF449 - CAS 389142-38-5 - Calbiochem
- CAS:
- 389142-38-5
- MF:
- C41H32N6O29S8
- MW:
- 1329.24
- Product Categories:
-
- Purinergics P2 receptor
- Mol File:
- 389142-38-5.mol
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NF449 Chemical Properties
- Melting point:
- >300°C
- Density
- 1.991±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- H2O: soluble
- form
- solid
- pka
- -2.03±0.50(Predicted)
- color
- white
- Stability:
- Hygroscopic
MSDS
- Language:English Provider:SigmaAldrich
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NF449 Usage And Synthesis
Uses
NF449 is a known P2X1 receptor antagonist used to regulate the intravascular platelet aggregation commonly seen in systematic thromboembolism.
Biological Activity
Potent purinergic receptor antagonist that displays high selectivity for P2X 1 (IC 50 values are 0.28, 0.69, 120, 1820, 47000 and > 300000 nM for rP2X 1 , rP2X 1+5 , rP2X 2+3 , rP2X 3 , rP2X 2 and P2X 4 receptors respectively). Provides antithrombotic protection in vivo . Also acts as a G s α -selective antagonist.
NF449Supplier
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