2-Amino-4-chlorophenol Chemical Properties

Melting point:

136-141 °C(lit.)

Boiling point:

185.5°C (rough estimate)

Density 

1.2028 (rough estimate)

refractive index 

1.5618 (estimate)

storage temp. 

2-8°C

solubility 

2.3g/l

Colour Index 

76525

pka

9.31±0.18(Predicted)

form 

Solid

color 

Pale Orange to Light Brown

Water Solubility 

Insoluble. <0.1 g/100 mL at 20 ºC

BRN 

774859

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

SWFNPENEBHAHEB-UHFFFAOYSA-N

CAS DataBase Reference

95-85-2(CAS DataBase Reference)

NIST Chemistry Reference

5-Chloro-2-hydroxyaniline(95-85-2)

IARC

2B (Vol. 123) 2020

EPA Substance Registry System

2-Amino-4-chlorophenol (95-85-2)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38-20/21/22

Safety Statements 

26-36-36/37/39

RIDADR 

UN 2673 6.1/PG 2

WGK Germany 

3

RTECS 

SJ5700000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

II

HS Code 

29222900

MSDS

• Language:English Provider:5-Chloro-2-hydroxyaniline
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-4-chlorophenol Usage And Synthesis

Chemical Properties

2-Amino-4-chlorophenol is a grayish to light brown crystalline solid or powder

Uses

Intermediate.

Uses

2-Amino-4-chlorophenol is a widely used reagent in the synthesis of various drugs, dyes and pesticides. A reagent in the synthesis of aggrecanase-2 inhibitors based on acylthiosemicarbazide zinc-binding, used in the treatment of osteoarthritis.

General Description

5-Chloro-2-hydroxyaniline is a light brown colored crystalline solid. 5-Chloro-2-hydroxyaniline may be toxic by ingestion. 5-Chloro-2-hydroxyaniline is insoluble in water. 5-Chloro-2-hydroxyaniline is used to make other chemicals.

Air & Water Reactions

5-Chloro-2-hydroxyaniline may be sensitive to prolonged exposure to air and/or light. Insoluble in water.

Reactivity Profile

5-Chloro-2-hydroxyaniline may react with strong oxidizing agents.

Health Hazard

Highly toxic, may be fatal if inhaled, swallowed or absorbed through skin. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Containers may explode when heated. Runoff may pollute waterways.

Safety Profile

A poison. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also AROMATIC MINES and CHLORIDES.

Potential Exposure

Used as a chemical raw material, especially in dye manufacture

Shipping

UN2673 2-Amino-4-chlorophenol, Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, iron, moisture and temperatures .43 C.

2-Amino-4-chlorophenol(95-85-2)Related Product Information

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