6-IODO-PYRIDIN-2-YLAMINE Chemical Properties

Melting point:

103-104°C

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

solid

Appearance

White to light yellow Solid

Safety Information

Hazard Codes 

Xi

HazardClass 

IRRITANT

HS Code 

2933399990

6-IODO-PYRIDIN-2-YLAMINE Usage And Synthesis

Synthesis

General procedure for the synthesis of 6-iodopyridin-2-amine from 2-amino-6-bromopyridine: 2-bromo-6-aminopyridine (519 mg), cuprous iodide (29 mg), sodium iodide (899 mg), and N,N-dimethylethylenediamine (26 mg) were dissolved in dioxane (5 mL) and heated to react for 6 hours at 110 °C in an inert atmosphere. Upon completion of the reaction, concentrated ammonia (8 mL) was added, followed by water (10 mL). The reaction mixture was extracted with dichloromethane (3 x 15 mL) and the organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by rapid chromatography on silica gel using a 0-10% methanol/dichloromethane gradient elution to afford 6-iodopyridin-2-amine as a beige solid (530 mg, 80% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 4.60 (s, 2H), 6.41-6.44 (m, 1H), 7.00-7.08 (m, 2H); mass spectrometry (MS) showed the molecular ion peak m/z 221 (MH+).

References

[1] RSC Advances, 2013, vol. 3, # 26, p. 10296 - 10300
[2] Patent: WO2005/60970, 2005, A1. Location in patent: Page/Page column 117

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