LEUKOTRIENE C4 Chemical Properties

Boiling point:

974.3±65.0 °C(Predicted)

Density 

1.225±0.06 g/cm3(Predicted)

Flash point:

11 °C

storage temp. 

−20°C

solubility 

50mg/mL in DMSO, or in DMF

form 

Liquid

pka

2.21±0.10(Predicted)

color 

Colorless to light yellow

Safety Information

Hazard Codes 

F,T

Risk Statements 

11-23/24/25-39/23/24/25

Safety Statements 

36/37-45-16-7

RIDADR 

UN 1230 3/PG 2

WGK Germany 

1

RTECS 

MB9143500

MSDS

• Language:English Provider:SigmaAldrich

LEUKOTRIENE C4 Usage And Synthesis

Description

Leukotriene C₄ (LTC₄) is the parent cysteinyl leukotriene produced by the LTC₄ synthase catalyzed conjugation of glutathione to LTA₄. LTC₄ is produced by neutrophils, macrophages, mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC₄-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC₄ required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM.

Uses

LTC4 (Leukotriene C4) is a potent agonist for contraction of smooth muscle, wtih many important immunomodulatory functions.

Definition

ChEBI: A leukotriene that contains cysteine in their structure.

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