1H-Imidazole-4-carboxylic acid Chemical Properties

Melting point:

294-295 °C (lit.)

Boiling point:

495.0±18.0 °C(Predicted)

Density 

1.524±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Aqueous Acid (sparingly)

form 

Liquid

pka

2.69±0.10(Predicted)

color 

Clear colorless

InChI

InChI=1S/C4H4N2O2/c7-4(8)3-1-5-2-6-3/h1-2H,(H,5,6)(H,7,8)

InChIKey

NKWCGTOZTHZDHB-UHFFFAOYSA-N

SMILES

C1NC(C(O)=O)=CN=1

CAS DataBase Reference

1072-84-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

NI4001000

HazardClass 

IRRITANT

HS Code 

29332900

MSDS

• Language:English Provider:SigmaAldrich

1H-Imidazole-4-carboxylic acid Usage And Synthesis

Chemical Properties

Gray or tan powder

Uses

4-Imidazolecarboxylic acid (ICA) was used in the synthesis of triphenymethyl-protected 4-imidazole carboxylic acid (trityl-ImCOOH) which is employed to functionalize poly(propylene imine) dendrimers.
It may be used in the following studies:

• In the synthesis of lanthanide sulfate–carboxylates, [Ln(HIMC)(SO₄)(H₂O)] (Ln = Dy and Eu, HIMC = 4-imidazolecarboxylic acid) by in situ decarboxylation in the presence of Cu(II) ions.
• As an internal standard to obtain calibration curve by plotting the peak area ratios of histamine (HA) and several metabolites isolated from C3H/HeNCrj mice hair relative to ICA.
• In the synthesis of tetranuclear manganese carboxylate complexes possessing imidazole-based N/O chelating ligands.

General Description

4-Imidazolecarboxylic acid (1H-imidazole-4-carboxylic acid, H₂imc) is an imidazole derivative that contains an imidazole group and a carboxylate group. It has been widely utilized to generate different types of coordination polymers. The anion of 4-imidazolecarboxylic acid has been reported to stabilize binuclear hydroxo complexes of trivalent lanthanides in the pH range 7-10.

1H-Imidazole-4-carboxylic acid(1072-84-0)Related Product Information

• 4-Aminobenzoic acid
• Levamisole
• Retinoic acid
• Calcium formate
• Bis(2-ethylhexyl) phthalate
• Ethyl imidazole-4-carboxylate
• Methyl formate
• Benzoic acid
• Imidazole
• Chromium picolinate
• 1-(1-phenylethyl)-imidazole-5-carboxylic acid ethyl ester
• 2-AMINO-9-(2,3,5-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)-6-THIOPURINE
• 1,9-DIHYDRO-6H-PURINE-6-THIONE
• 6-N-HEPTYLMERCAPTOPURINE
• 2-Amino-6-mercaptopurine-13C2,15N
• 6,8-DIHYDROXY-2-METHYLMERCAPTOPURINE
• 6-(Methylthio)purine
• 6-thioinosine-5'-triphosphate