TUFTSIN
TUFTSIN Basic information
- Product Name:
- TUFTSIN
- Synonyms:
-
- TUFTSIN
- TUFTSIN 2ACOH 4H2O
- THR-LYS-PRO-ARG
- THR-LYS-PRO-ARG 2ACOH 4H2O
- Tuftsin hydrate acetate salt
- L-Thr-L-Lys-L-Pro-L-Arg-OH
- Taftsin
- Tuftsin Tuftsin acetate salt hydrate
- CAS:
- 9063-57-4
- MF:
- C21H40N8O6
- MW:
- 500.59
- Product Categories:
-
- Peptide
- Mol File:
- 9063-57-4.mol
TUFTSIN Chemical Properties
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- form
- Solid
- pka
- 3.60±0.21(Predicted)
- color
- White to off-white
- Water Solubility
- Water : ≥ 160 mg/mL (319.62 mM)
- Sequence
- H-Thr-Lys-Pro-Arg-OH
TUFTSIN Usage And Synthesis
Uses
Tuftsin is an immunostimulatory agent that induces bactericidal and tumoricidal activity by promoting phagocytosis, antigen presentation and cell migration.
Biological Activity
Tuftsin is a tetrapeptide and a macrophage/microglia activator.
in vitro
Tuftsin is a tetrapeptide, Thr-Lys-Pro-Arg, which resides in the Fc-domain of the heavy chain of immunoglobulin G. Tuftsin possesses a broad spectrum of activities related primarily to the immune system function and exerts on phagocytic cells, notably on macrophages. Tuftsin's capacity to augment cellular activation is mediated by specific receptors that are identified, characterized, and recently isolated from rabbit peritoneal granulocytes. Tuftsin, a macrophage/microglial activator, dramatically improves the clinical course of experimental autoimmune encephalomyelitis (EAE), a well-established animal model for MS. Tuftsin administration correlates with upregulation of the immunosuppressive Helper-2 Tcell (Th2) cytokine transcription factor GATA-3. Tuftsin promotes phagocytic activity for cells of monocytic origin, such as neutrophils, macrophages and microglia, all of which are thought to express Tuftsin receptors.
target
| Human Endogenous Metabolite < span> |
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