3,4-DIHYDROQUINOLIN-2(1H)-ONE Chemical Properties

Melting point:

165-167 °C (lit.)

Boiling point:

267.28°C (rough estimate)

Density 

1.1135 (rough estimate)

refractive index 

1.5200 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml

form 

Crystalline Powder

pka

14.76±0.20(Predicted)

color 

Off-white

Water Solubility 

Slightly soluble in water.

Sensitive 

Light Sensitive

Merck 

13,4800

CAS DataBase Reference

553-03-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38-43

Safety Statements 

26-36/37

RIDADR 

2811

WGK Germany 

2

Hazard Note 

Irritant

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29337900

MSDS

• Language:English Provider:3,4-Dihydro-2(1H)-quinolinone
• Language:English Provider:SigmaAldrich

3,4-DIHYDROQUINOLIN-2(1H)-ONE Usage And Synthesis

Chemical Properties

Off-white crystalline powder

Uses

3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.

Uses

3,4-Dihydro-2(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments.

Definition

ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.

Synthesis Reference(s)

Journal of the American Chemical Society, 89, p. 7131, 1967 DOI: 10.1021/ja01002a061
Tetrahedron Letters, 36, p. 125, 1995 DOI: 10.1016/0040-4039(94)02191-D

General Description

Series of 3,4-dihydro-2(1H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)H)-quinolinones have been synthesized using N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase

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