CALCINEURIN
CALCINEURIN Basic information
- Product Name:
- CALCINEURIN
- Synonyms:
-
- Calcineurin bovine brain
- CALCINEURIN FROM BOVINE BRAIN, >10 U/MG
- calcium/calmodulin-activated protein phosphatase
- MODULATOR BINDING PROTEIN
- PP2B
- PPASE-2B
- PROTEIN PHOSPHATASE 2B, HUMAN, RECOMBINANT, E COLI
- PROTEIN PHOSPHATASE 2B
- CAS:
- 90371-51-0
- MW:
- 0
- Mol File:
- Mol File
CALCINEURIN Chemical Properties
- storage temp.
- −20°C
- solubility
- H2O: soluble
- form
- lyophilized powder
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
CALCINEURIN Usage And Synthesis
Uses
Calcineurin from bovine brain has been used:
- as a positive control in western blot analysis of oocytes and cumulus cells proteome
- as a positive control in calmodulin (CaM)-agarose binding assay
- to test its phosphatase activity in the presence of okadaic acid
General Description
Calcineurin (CaN) comprises CaN A and CaN B subunits. It exists as a heterodimer with a calmodulin-binding domain, catalytic site, a CaN B binding domain, and an autoinhibitory domain.
Biochem/physiol Actions
Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.
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