4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Chemical Properties

Melting point:

115 °C

Boiling point:

471.2±35.0 °C(Predicted)

Density 

1.476±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in DMSO (30 mg/ml)

form 

solid

color 

White to off-white

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

HazardClass 

IRRITANT

HS Code 

2930909899

4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Usage And Synthesis

Description

BTB-1 (86030-08-2) is a? selective, ATP-competitive and reversible inhibitor of mitotic kinesin Kif18A, IC50=1.7 mM.1,2 Binds to an allosteric site near Kif18A loop 5 preventing a range of conformational changes thereby blocking motor function.3 Inhibits the differentiation of mouse bone marrow cells to dendritic cells.4 Suppresses the replication of influenza A virus, inhibiting activation of AKT, p38 MAPK, SAPK and RanBP3 leading to the prevention of nuclear export of viral ribonucleoprotein complexes. Greatly improves the viability of IAV-infected mice.5

Uses

BTB 1 is a small molecular inhibitor of the mitotic motor protein Kif18A.

storage

Store at +4°C

References

[1] MARIO CATARINELLA. BTB-1: A Small Molecule Inhibitor of the Mitotic Motor Protein Kif18A†[J]. Angewandte Chemie International Edition, 2009, 48 48: 9072-9076. DOI:10.1002/anie.200904510
[2] JOACHIM BRAUN. Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A[J]. ACS Chemical Biology, 2014, 10 2: 554-560. DOI:10.1021/cb500789h
[3] JULIA LOCKE. Structural basis of human kinesin-8 function and inhibition.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2017: E9539-E9548. DOI:10.1073/pnas.1712169114
[4] Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells
[5] YONG-BIN CHO. Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus[J]. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 24 10: 5463-5475. DOI:10.1111/jcmm.15200

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