Monalizumab
Monalizumab Basic information
- Product Name:
- Monalizumab
- Synonyms:
-
- Monalizumab
- Research Grade Monalizumab(DHD71901)
- Research Grade Monalizumab
- Monalizumab (anti-NKG2A)
- CAS:
- 1228763-95-8
- MW:
- 0
- Mol File:
- Mol File
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Monalizumab Chemical Properties
- storage temp.
- Store at -20°C
- form
- Liquid
- color
- Colorless to light yellow
- Water Solubility
- Soluble in water
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Monalizumab Usage And Synthesis
Uses
Monalizumab (IPH2201) is a potentially first-in-class immune checkpoint inhibitor targeting NKG2A receptors expressed on tumor infiltrating cytotoxic CD8+ T cells and NK cells.
Mechanism of action
Monalizumab is a blocking antibody that prevents the inhibition of CD8+ T cells and NK cell by tumor cells expressing HLA-E. By acting simultaneously on innate and adaptive immunity, monalizumab may re-establish a broad anti-tumor response.
in vivo
Monalizumab (50 ?μg, intratumoral injections, together with 8?millions of activated NK cells) effectively inhibits tumor growth in xenografted HLA-E+ tumors in immunodeficient mice[4].
| Animal Model: | immunodeficient mice xenografted with Cal-27 HLA-E high tumor cell[4] |
| Dosage: | 50?μg, together with 8?millions of activated NK cells |
| Administration: | intratumoral injections |
| Result: | Shows a synergestic antitumor effect. Enhanced NK-cell killing, and induces lysis of tumor cells. |
MonalizumabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
ShangHai Biochempartner Co.,Ltd
- Tel
- 177-54423994 17754423994
- 2853530910@QQ.com
Beijing Solarbio Science & Tecnology Co., Ltd.
- Tel
- 010-50973130 18101056239
- 3193328036@qq.com
Guangzhou Hongyuan Chemical Co.,Ltd
- Tel
- 15817493340
- 981810490@qq.com
Wuhan Chemstan Biotechnology Co., Ltd.
- Tel
- 027-65317797 15926423062
- 422450190@qq.com