2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Chemical Properties

Boiling point:

1273.8±65.0 °C(Predicted)

Density 

1.296±0.06 g/cm3(Predicted)

form 

Solid

pka

3.56±0.10(Predicted)

color 

White to off-white

2-8-Angiotensin II, 2-glycine-5-L-isoleucine- Usage And Synthesis

Uses

TRV055, a G-protein-biased agonist, is a Gq-biased ligand of the angiotensin II receptor type 1 (AT1R). TRV055 is efficacious in stimulating cellular Gq-mediated signaling[1].

IC 50

AT1 Receptor

References

[1] Laura M Wingler, et al. Angiotensin Analogs with Divergent Bias Stabilize Distinct Receptor Conformations. Cell. 2019 Jan 24;176(3):468-478.e11. DOI:10.1016/j.cell.2018.12.005

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