L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Chemical Properties

Boiling point:

1151.3±65.0 °C(Predicted)

Density 

1.324±0.06 g/cm3(Predicted)

storage temp. 

-20°C, protect from light, stored under nitrogen

solubility 

DMSO: 100 mg/mL (146.68 mM; ultrasonic and warming and heat to 80°C)

form 

Solid

pka

4.44±0.10(Predicted)

color 

White to off-white

L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI) Usage And Synthesis

Biological Activity

Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing[1]. Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1].

References

[1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015;6:8762. Published 2015 Nov 9.

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