1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDE
1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDE Basic information
- Product Name:
- 1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDE
- Synonyms:
-
- 184832
- Co 101244
- 1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDE
- CO 101244 HYDROCHLORIDE
- 1-[2-(4-Hydroxyphenoxy)ethyl]-4-[(4-methylphenyl)methyl]-4-piperidinolhydrochloride
- 4-Piperidinol, 1-[2-(4-hydroxyphenoxy)ethyl]-4-[(4-Methylphenyl)Methyl]-
- 1-(2-(4-hydroxyphenoxy)ethyl)-4-(4-methylbenzyl)piperidin-4-ol
- CO-101244 Free Base
- CAS:
- 193359-26-1
- MF:
- C21H27NO3
- MW:
- 341.44
- Mol File:
- 193359-26-1.mol
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1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDE Chemical Properties
- Boiling point:
- 527.9±45.0 °C(Predicted)
- Density
- 1.169±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- pka
- 10.31±0.15(Predicted)
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1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDE Usage And Synthesis
Uses
Co 101244 is a highly selective N-methyl-D-aspartate NR2B subtype antagonist.
Biological Activity
Novel, potent and selective antagonist of NR2B-containing NMDA receptors (IC 50 values are 0.043, > 100 and > 100 μ M for NR1A/2B, NR1A/2A and NR1A/2C subunit combinations respectively). Displays neuroprotective effects in vivo and in vitro .
1-[2-(4-HYDROXYPHENOXY)ETHYL]-4-[(4-METHYLPHENYL)METHYL]-4-PIPERIDINOL MONOHYDROCHLORIDESupplier
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