N,N′-Diisoprophyl phosphordiamide fluoride Chemical Properties

Melting point:

65°

Boiling point:

125.5°C

Density 

1.2 g/cm3(Temp: 25 °C)

pka

-2.71±0.70(Predicted)

form 

solid

Water Solubility 

74.07g/L(temperature not stated)

EPA Substance Registry System

Mipafox (371-86-8)

Safety Information

Hazard Codes 

T+

Risk Statements 

39/26/27/28

Safety Statements 

13-45

RIDADR 

2783

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

371-86-8(Hazardous Substances Data)

Toxicity

Formerly used as a systemic insecticide. Its use was discontinued because of severe delayed neuropathy hazard in humans. The oral LD50/LC50 in rabbits is 100 mg/kg. Toxic action is as a neurotoxicant with both acute and delayed actions, acting as a cholinesterase inhibitor (acute toxicity) and as a neurotoxic esterase inhibitor (possibly linked to delayed toxicity). Symptoms in humans are typical anticholinesterase symptoms. Therapy is supportive as well as atropine sulfate and 2-PAM.

N,N′-Diisoprophyl phosphordiamide fluoride Usage And Synthesis

Uses

Mipafox is an insecticide.

Uses

Insecticide.

Definition

ChEBI: Mipafox is a phosphoramide.

Hazard

Cholinesterase inhibitor.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of F-, NOx, and POx. See also PARATHION and FLUORIDES.

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