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MAF

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MAF Basic information

Product Name:
MAF
Synonyms:
  • Ferric methylarsonate
  • Methoxyacetyl fentanyl hydrochloride solution
  • good quality 99.5% MAF with lowest price
  • MAF 5F-MDMB-2201 methoxyaceylfentanyl
  • MAF power
  • MAF
  • IFN-γ human
  • Immune Interferon
CAS:
101365-54-2
MF:
C22H29ClN2O2
MW:
388.94
Product Categories:
  • pharmaceutical intermediates
  • research chemical
  • Chemical and pharmaceutical intermediates
  • Medical research
  • pharmaceutical intermediate or chemical research
Mol File:
Mol File
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MAF Chemical Properties

storage temp. 
-20°C
solubility 
DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 20 mg/ml; Methanol: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A neat solid
Stability:
Hygroscopic
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Safety Information

RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
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MAF Usage And Synthesis

Uses

IFN-γ (interferon γ)-human has been used for the generation of inflammatory M1 cells from human monocytic cell line, THP1.

General Description

IFN-γ (interferon γ) is an acid-labile glycosylated interferon produced by CD4 and CD8 T lymphocytes as well as activated NK (natural killer) cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC (major histocompatibility complex) proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. The gene is mapped to human chromosome 12q15. Human IFN-γ is species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7kDa protein containing 143 amino acid residues.

Biochem/physiol Actions

IFN-γ (interferon γ) signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. It can suppress the generation of anti-inflammatory cytokines and enhance the secretion of proinflammatory cytokines. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK (natural killer) cells and neutrophils. It is responsible for tumor rejection and is capable of killing tumor cells by autophagy or apoptosis. IFN-γ is also involved in Hepatitis E virus disease pathogenesis.

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