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5-Chloro-2-methoxyaniline

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5-Chloro-2-methoxyaniline Basic information

Product Name:
5-Chloro-2-methoxyaniline
Synonyms:
  • 2-Amino-4-chioroanisole
  • 5-chloro-2-methoxy-benzenamin
  • C.I.37120(base)
  • C.I.Azoic Diazo Component 10(base)
  • Tulabase Fast Red R
  • 5-Chloro-o-anisidine 4-Chloro-2-aminoanisole 2-Amino-4-chloroanisole
  • 5-Chloro-o-anisidine,98%
  • 5-Chloro-2-methoxyaniline 98%
CAS:
95-03-4
MF:
C7H8ClNO
MW:
157.6
EINECS:
202-385-2
Product Categories:
  • API Intermediate
  • Anilines, Aromatic Amines and Nitro Compounds
  • Intermediates of Dyes and Pigments
Mol File:
95-03-4.mol
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5-Chloro-2-methoxyaniline Chemical Properties

Melting point:
81-83 °C(lit.)
Boiling point:
135 °C (5.85078 mmHg)
Density 
1.1760 (rough estimate)
refractive index 
1.5430 (estimate)
Flash point:
136 °C
storage temp. 
Amber Vial, -20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Solid
pka
3.48±0.10(Predicted)
color 
Pale Grey to Light Grey
BRN 
879161
Stability:
Light Sensitive
CAS DataBase Reference
95-03-4(CAS DataBase Reference)
EPA Substance Registry System
Benzenamine, 5-chloro-2-methoxy- (95-03-4)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36/37
RIDADR 
UN 2233 6.1/PG 3
WGK Germany 
3
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29222990

MSDS

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5-Chloro-2-methoxyaniline Usage And Synthesis

Chemical Properties

Off-white to tan crystalline powder or flakes

Uses

5-Chloro-2-methoxybenzenamine is used in preparation of appetite-modulating molecules.

Preparation

4-Chloro-1-methoxy-2-nitrobenzene reduction.

Purification Methods

Purify the aniline by steam distillation and recrystallisation from H2O or 40% aqueous EtOH. The N-acetate forms needles from hot H2O with m 104o, the N-benzoyl derivative forms needles from aqueous EtOH with m 77-78o, and the picrate has m 194o(dec). [Raiford & Colbert J Am Chem Soc 48 2657 1926, Beilstein 13 IV 879.]

5-Chloro-2-methoxyaniline Preparation Products And Raw materials

Raw materials

5-Chloro-2-methoxyanilineSupplier

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