bucumolol hydrochloride
bucumolol hydrochloride Basic information
- Product Name:
- bucumolol hydrochloride
- Synonyms:
-
- bucumolol hydrochloride
- Bucumalol
- (+-)-5-Methyl-8-(2-hydroxy-3-tert-butylaminopropoxy)coumarin hydrochloride
- 8-(2-Hydroxy-3-tert-butylaminopropoxy)-5-methylcoumarin hydrochloride
- Bucumarol
- CS 359
- DL-5-Methyl-8-(2-hydroxy-3-tert-butylaminopropoxy)coumarin hydrochloride
- dl-Bucumolol hydrochloride
- CAS:
- 36556-75-9
- MF:
- C17H23NO4.ClH
- MW:
- 341.833
- Mol File:
- 36556-75-9.mol
More
Less
bucumolol hydrochloride Chemical Properties
- Melting point:
- 226-228° (dec)
More
Less
More
Less
bucumolol hydrochloride Usage And Synthesis
Originator
Bucumarol,Sankyo,Japan,1982
Definition
ChEBI: Bucumolol hydrochloride is a member of coumarins.
Manufacturing Process
A mixture of 3 g of 8-(2-hydroxy-3-chloropropoxy)-5-methyl coumarin, 4.3 g
of t-butylamine and 60 ml of ethanol is heated at 100°C in a sealed tube for
15 hours. The reaction mixture is concentrated under reduced pressure to
dryness. The residue is recrystallized from a mixture of ethanol and ether to
give 2.1 g of the desired product melting at 226° to 228°C (with
decomposition).
In practice it is usually used as hydrochloride.
Therapeutic Function
Beta-adrenergic blocker