bucumolol hydrochloride Chemical Properties

Melting point:

226-228° (dec)

Safety Information

Toxicity

LD50 in male, female mice (mg/kg): 676, 692 orally; 33.1, 31.6 i.v. (Oshima)

bucumolol hydrochloride Usage And Synthesis

Originator

Bucumarol,Sankyo,Japan,1982

Definition

ChEBI: Bucumolol hydrochloride is a member of coumarins.

Manufacturing Process

A mixture of 3 g of 8-(2-hydroxy-3-chloropropoxy)-5-methyl coumarin, 4.3 g of t-butylamine and 60 ml of ethanol is heated at 100°C in a sealed tube for 15 hours. The reaction mixture is concentrated under reduced pressure to dryness. The residue is recrystallized from a mixture of ethanol and ether to give 2.1 g of the desired product melting at 226° to 228°C (with decomposition).
In practice it is usually used as hydrochloride.

Therapeutic Function

Beta-adrenergic blocker

bucumolol hydrochloride(36556-75-9)Related Product Information

• AKOS BC-1945
• bucumolol hydrochloride
• 3-(2-ethoxyphenoxy)propan-1-amine
• OXPRENOLOL HYDROCHLORIDE
• oxprenolol
• moprolol
• Bucumolol
• 3-(2-methoxyphenoxy)propan-1-amine