Promazine Chemical Properties

Melting point:

25°C

Boiling point:

bp0.3 203-210°

Density 

1.1256 (rough estimate)

refractive index 

1.6000 (estimate)

solubility 

Chloroform (Slightly), Methanol (Slightly)

pka

pKa 9.4(H2O,t =24±1) (Uncertain)

form 

Solid

color 

Off-White to Pale Beige

Water Solubility 

14.22mg/L(24 ºC)

Stability:

Hygroscopic

NIST Chemistry Reference

Promazine(58-40-2)

Safety Information

Hazardous Substances Data

58-40-2(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 350mg/kg

Promazine Usage And Synthesis

Uses

ntipsychotic.

Uses

In psychiatric practice, promazine is used in minor cases of psychomotor excitement in schizophrenics, in paranoid and manic-depressive conditions, for neurosis, alcoholic psychosis, and others. It is sometimes used in anesthesiological practice.

Uses

Promazine is an antipsychotic and a tranquilizer.

Definition

ChEBI: A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.

brand name

Sparine (Baxter Healthcare); Sparine (Wyeth).

General Description

Promazine, 10-[3-(dimethylamino) propyl-(phenothiazine monohydrochloride (Sparine), was introducedinto antipsychotic therapy after its 2-chloro-substitutedrelative. The 2H-substituent vis-à-vis the 2Clsubstituent gives a milligram potency decrease as an antipsychotic,as encompassed in Gordon’s rule. Tendency toEPS is also lessened, which may be significant, especially ifit is decreased less than antipsychotic potency.

Synthesis

Promazine, 10-(3-dimethylaminopropyl)phenothiazine (6.1.1), is prepared by the alkylation of phenothiazine with 3-dimethylaminopropylchloride in the presence of sodium amide [1¨C3].

Promazine(58-40-2)Related Product Information

• Dimethyl sulfate
• N,N-Dimethylcyclohexylamine
• ETHANE
• Chlorpromazine hydrochloride
• Dimethyl carbonate
• Phenothiazine
• Cyromazine
• Dimethyl fumarate
• Imipramine hydrochloride
• Dimethyl sulfoxide
• N,N-Dimethylformamide
• N,N-Dimethyldodecylamine
• N,N-Dimethylallylamine
• IMIPRAMINE
• Dimethyl sulfide
• Dimethyl ether
• DIOXOPROMETHAZINE HCL
• acepromazine