trimetozine Chemical Properties

Melting point:

120-122°

Boiling point:

423.97°C (rough estimate)

Density 

1.1755 (rough estimate)

refractive index 

1.5230 (estimate)

pka

-1.60±0.20(Predicted)

form 

Solid

color 

White to off-white

Safety Information

Toxicity

LD50 oral in rat: 1800mg/kg

trimetozine Usage And Synthesis

Originator

Opalene,Theraplix,France,1966

Uses

antiurolithic, depigmentation, radiation protectant

Uses

A sedative with mild tranquilizing effects. It has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine.

Uses

A sedative with mild tranquilizing effects. Trimetozine has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine.

Definition

ChEBI: 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone is a member of morpholines.

Manufacturing Process

46 g 3,4,5-trimethoxybenzoyl chloride are dissolved in 300 ml anhydrous benzene and 25 g triethylamine and thereafter 19 g anhydrous morpholine are added in small portions with ice-cooling. The solution is boiled for 2 hours under reflux. The precipitate is filtered off, and the solution is washed with dilute sulfuric acid, then with sodium hydrogen carbonate solution and finally with water, and then evaporated. The residual yellow oil soon crystallizes; the crystalline mass of the desired material is taken up with ether, filtered and then recrystallized from 90% ethanol, from which it separates in prisms. It is slightly soluble in water. Yield: 80%. melting point 120°C to 122°C.

Therapeutic Function

Sedative

trimetozine(635-41-6)Related Product Information

• 3,5-DIMETHOXY-4-HYDROXYBENZAMIDE
• (3,5-DIMETHOXYBENZYL)METHYLAMINE
• N-Formylmorpholine
• 3,5-Dimethoxybenzylamine
• ETHAMIVAN
• N-METHYL-3,4,5-TRIMETHOXYBENZYLAMINE
• 3-METHOXY-N,N-DIMETHYLBENZYLAMINE
• 3,4,5-TRIMETHOXYBENZAMIDE
• 3,4-DIHYDROXYBENZAMIDE
• N,N-DIETHYLBENZAMIDE
• N-Acetylmorpholine
• N-Benzyl-N-methylethanolamine
• 3,5-Dimethoxybenzaldehyde
• DIMETHYLAMINOMETHYLPHENOL
• 3,4,5-Trimethoxybenzaldehyde
• 4-Methoxybenzamide
• 3,4,5-TRIHYDROXYBENZAMIDE
• Veratrylamine