mefruside Chemical Properties

Melting point:

149.5°C

Boiling point:

565.2±60.0 °C(Predicted)

Density 

1.3150 (rough estimate)

refractive index 

1.6100 (estimate)

storage temp. 

Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility 

Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

9.26±0.60(Predicted)

color 

White to Pale Beige

Stability:

Hygroscopic

Safety Information

Toxicity

LD50 oral in rabbit: > 3gm/kg

mefruside Usage And Synthesis

Originator

Baycaron,Bayer,W. Germany,1967

Uses

Mefruside is a diuretic used for the treatment of edema and hypertension.

Definition

ChEBI: Mefruside is an organic molecular entity.

Manufacturing Process

By hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol.

Therapeutic Function

Diuretic

mefruside(7195-27-9)Related Product Information

• 2-Methyltetrahydrofuran
• Furfurylamine
• mefruside
• CLOFENAMIDE
• tetrahydrofurfuryl-2-methylamine