4,4'-propylenebis(piperazine-2,6-dione) Chemical Properties

Melting point:

237-239°

Boiling point:

411.43°C (rough estimate)

Density 

1.2576 (rough estimate)

refractive index 

1.6081 (estimate)

storage temp. 

Inert atmosphere,2-8°C

solubility 

DMSO: soluble40mg/mL

form 

solid

pka

11.00±0.20(Predicted)

color 

White to off-white

Water Solubility 

3g/L(25 ºC)

Safety Information

WGK Germany 

3

RTECS 

TL6389900

4,4'-propylenebis(piperazine-2,6-dione) Usage And Synthesis

Uses

Razoxane is an inhibitor of Topo II.

Definition

ChEBI: Razoxane is a N-alkylpiperazine.

Biological Activity

Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown th at razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.

Safety Profile

Suspected human carcinogen producing leukemia and skin tumors. Moderately toxic by intraperitoneal route. Human effects: normocytic anemia and thrombocytopenia. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

4,4'-propylenebis(piperazine-2,6-dione) (21416-67-1)Related Product Information

• polyethyleneimine
• Dexrazoxane
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