canadine
canadine Basic information
- Product Name:
- canadine
- Synonyms:
-
- (13As)-5,8,13,13A-tetrahydro-9,10-dimethoxy-6H-benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine
- (S)-Canadine
- (S)-Tetrahydroberberine
- C03329
- 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8,13,13a-tetrahydro-9,10-dimethoxy-, (13aS)-
- (-)-Canadine
- CAS:
- 5096-57-1
- MF:
- C20H21NO4
- MW:
- 339.39
- EINECS:
- 225-815-0
- Mol File:
- 5096-57-1.mol
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canadine Chemical Properties
- Melting point:
- 135°
- alpha
- D22 -308°; -317° (c = 0.28; 0.4, both in methanol)
- Boiling point:
- 475.36°C (rough estimate)
- Density
- 1.2270 (rough estimate)
- refractive index
- 1.6000 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform, Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated)
- form
- Solid
- pka
- 6.53±0.20(Predicted)
- color
- Pale Yellow to Light Yellow
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canadine Usage And Synthesis
Chemical Properties
Yellow Solid
Uses
(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents.
Definition
ChEBI: (S)-canadine is the (S)-enantiomer of canadine. It has a role as a plant metabolite. It is functionally related to a (S)-nandinine. It is an enantiomer of a (R)-canadine.
target
P450 (e.g. CYP17)
canadine Supplier
J & K SCIENTIFIC LTD.
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- 010-82848833 400-666-7788
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- +86-21-20908456
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BioBioPha Co., Ltd.
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- 0871-65217109 13211707573;
- y.liu@mail.biobiopha.com
Shanghai JONLN Reagent Co., Ltd.
- Tel
- 400-0066400 13621662912
- 422131432@qq.com
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canadine (5096-57-1)Related Product Information
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