canadine Chemical Properties

Melting point:

135°

alpha 

D22 -308°; -317° (c = 0.28; 0.4, both in methanol)

Boiling point:

475.36°C (rough estimate)

Density 

1.2270 (rough estimate)

refractive index 

1.6000 (estimate)

storage temp. 

Refrigerator

solubility 

Chloroform, Ethyl Acetate (Slightly), Methanol (Very Slightly, Heated)

form 

Solid

pka

6.53±0.20(Predicted)

color 

Pale Yellow to Light Yellow

Safety Information

RIDADR 

1544

HazardClass 

6.1(b)

PackingGroup 

III

canadine Usage And Synthesis

Chemical Properties

Yellow Solid

Uses

(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as n ew antipsychotic agents.

Uses

(S)-(-)-Canadine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Canadine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling. (S)-(-)-Canadine has a strong central nervous system-depressing activity and is used in the preparation of tetrahydroprotoberberine derivatives as new antipsychotic agents.

Definition

ChEBI: (S)-canadine is the (S)-enantiomer of canadine. It has a role as a plant metabolite. It is functionally related to a (S)-nandinine. It is an enantiomer of a (R)-canadine.

target

P450 (e.g. CYP17)

canadine (5096-57-1)Related Product Information

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