2-bromo-4-ethylacetophenone Chemical Properties

Melting point:

33-34 °C

Boiling point:

289.4±23.0 °C(Predicted)

Density 

1.360±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

Appearance

Off-white to yellow Solid

2-bromo-4-ethylacetophenone Usage And Synthesis

Synthesis

Preparation of 2-bromo-1-(4-ethylphenyl)ethanone (Chem. Plextr. Reg. No. 2632-14-6): 4'-Ethylacetophenone (9 mL, 60 mmol) was dissolved in 100 mL of anhydrous tetrahydrofuran, and cooled to 0 °C. Subsequently, phenyltrimethylammonium tribromide (22.6 g, 60 mmol) was added in batches and slow formation of precipitate was observed. The reaction mixture was stirred continuously at 0 °C for 1 h, after which stirring was continued at room temperature for 20 min. The concentrated reaction mixture was diluted with 200 mL of ether, washed sequentially with water (3 x 150 mL) and brine, then dried with magnesium sulfate and filtered. The filtrate was concentrated to afford the target product 2-bromo-1-(4-ethylphenyl)ethanone (15.9 g, quantitative yield). Mass spectrometry analysis showed m/z: 227, 229.03 (Br isotope mode); HPLC analysis with a retention time of 18.6 min (purity >99%).

References

[1] Patent: WO2008/84300, 2008, A1. Location in patent: Page/Page column 35
[2] Heterocycles, 1992, vol. 34, # 4, p. 747 - 756
[3] Journal of Heterocyclic Chemistry, 2013, vol. 50, # SUPPL.1, p. E126-E130
[4] Synthetic Communications, 2013, vol. 43, # 19, p. 2603 - 2614
[5] RSC Advances, 2016, vol. 6, # 79, p. 75651 - 75663

2-bromo-4-ethylacetophenone (2632-14-6)Related Product Information

• 2-BROMO-1-(5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE
• 4-Ethylacetophenone
• 2-BROMO-1-(4-PENTYLPHENYL)ETHAN-1-ONE
• 2,7-DIBROMO-1,3,6,8(2H,7H)-PYRENETETRONE
• 2-BROMO-1-(4-CYCLOHEXYLPHENYL)ETHANONE
• 2-bromo-4-ethylacetophenone
• 4-(TERT-BUTYL)-2,6-DIMETHYL-3,5-DINITROPHENACYL BROMIDE
• 2-BROMO-1-(4-ISOBUTYL PHENYL)-1-PROPANONE
• 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-ETHANONE
• 2-bromo-4-isopropylacetophenone
• 2-BROMO-1-(3-ETHYL-5,5,8,8-TETRAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)ETHAN-1-ONE
• 2-BROMO-1-(4-TERT-BUTYL-PHENYL)-PENTAN-1-ONE
• 2-BROMO-1-(4-BENZYL-PHENYL)-ETHANONE
• ALPHA,ALPHA'-DIBROMO-2,5-DIMETHOXY-1,4-DIACETYLBENZENE
• [1-BROMO-2-(1,2-DIHYDROACENAPHTHYLEN-5-YL)-2-OXOETHYL](TRIPHENYL)PHOSPHONIUM
• 2-BROMO-4'-(3-METHYLPROP-1-YL)PROPIOPHENONE
• AKOS BB-3118