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Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate

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Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate Basic information

Product Name:
Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
Synonyms:
  • Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate
  • Methyl 2-hydroxypyridine-4-carboxylate
  • Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate 98%
  • 4-Pyridinecarboxylicacid,1,2-dihydro-2-oxo-,methylester(9CI)
  • Methyl 2-oxo-1,2-dihydropyridine-4-carboxylate
  • Methyl 2-hydroxypyridine-...
  • Methyl 2-hydroxypyridine-4-carboxylate, 1,2-Dihydro-4-(methoxycarbonyl)-2-oxopyridine
  • Methyl1,2-dihydro-2-oxopyridine-4-carboxylate98%
CAS:
89937-77-9
MF:
C7H7NO3
MW:
153.14
Product Categories:
  • blocks
  • Pyridines
  • CARBOXYLICESTER
  • Heterocycle-Pyridine series
Mol File:
89937-77-9.mol
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Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate Chemical Properties

Melting point:
211-212 °C
Boiling point:
342.4±42.0 °C(Predicted)
Density 
1.263±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
pka
11.02±0.10(Predicted)
color 
White to off-white
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Safety Information

Hazard Codes 
Xi
RIDADR 
UN2811
Hazard Note 
Irritant
HS Code 
2933399990
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Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate Usage And Synthesis

Uses

Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is an ester derivative, mainly used as a pharmaceutical intermediate.

Synthesis

The synthesis method of Methyl 1,2-dihydro-2-oxopyridine-4-carboxylate is as follows: Dissolve 10 g (0.066 mol) of m-nitrobenzaldehyde and 11 g (0.067 mol) of ethyl chloroacetate in 60 ml of benzene, and add 1 ml of piperidine. 1 ml of glacial acetic acid, heated in a water bath, and the water generated in the reaction was continuously removed with a Dean-start water separator. After refluxing for 3h, the benzene was evaporated, 20ml of ether was added to the residue, frozen, crystallized, suction filtered, and dried to give 16.2g of methyl 2-hydroxypyridine-4-carboxylate, yield 82%, mp 92 -96°C.

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