2,4-Dichloro-3-nitropyridine Chemical Properties

Melting point:

61.5-62 °C

Boiling point:

285.7±35.0 °C(Predicted)

Density 

1.629±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

powder to crystal

pka

-2.49±0.10(Predicted)

color 

White to Orange to Green

InChI

InChI=1S/C5H2Cl2N2O2/c6-3-1-2-8-5(7)4(3)9(10)11/h1-2H

InChIKey

RTXYIHGMYDJHEU-UHFFFAOYSA-N

SMILES

C1(Cl)=NC=CC(Cl)=C1[N+]([O-])=O

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

HazardClass 

IRRITANT

HS Code 

2933399990

2,4-Dichloro-3-nitropyridine Usage And Synthesis

Description

2,4-Dichloro-3-nitropyridine is a halogenated pyridinium salt that has been shown to inhibit the influenza virus in vitro. This compound is also reactive with nucleophilic groups such as amines, alcohols, and thiols. 2,4-Dichloro-3-nitropyridine has been used for the synthesis of quinoline derivatives that have potential applications in autoimmune diseases or cancer. 2,4-Dichloro-3-nitropyridine has also been found to be an inhibitor of tumor necrosis factor alpha (TNFα) production by LPS stimulated human monocytes.

Chemical Properties

Light yellow needles

Uses

2,4-Dichloro-3-nitropyridine is a reactant in the discovery of Imigliptin, a novel selective dipeptidyl peptidase IV (DPP-4) inhibitor used in the treatment of type 2 diabetes.

2,4-Dichloro-3-nitropyridine(5975-12-2)Related Product Information

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