ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyridine compound > Chloropyridine > 4-Chloropyridine-3-carboxamide
4-Chloropyridine-3-carboxamide
4-Chloropyridine-3-carboxamide Basic information
- Product Name:
- 4-Chloropyridine-3-carboxamide
- Synonyms:
-
- 4-Chloropyridine-3-carboxamide
- 4-Chloro-3-pyridinecarboxaMide
- 4-Chloropyridine-3-carboxamide ISO 9001：2015 REACH
- 3-Pyridinecarboxamide, 4-chloro-
- CAS:
- 7418-70-4
- MF:
- C6H5ClN2O
- MW:
- 156.57
- Product Categories:
-
- Pyridines
- Mol File:
- 7418-70-4.mol
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4-Chloropyridine-3-carboxamide Chemical Properties
- Boiling point:
- 299.5±25.0 °C(Predicted)
- Density
- 1.381±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- pka
- 14.19±0.50(Predicted)
- Appearance
- Light yellow to yellow Solid
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4-Chloropyridine-3-carboxamide Usage And Synthesis
Synthesis
10177-29-4
7418-70-4
Step A: Preparation of 4-chloronicotinamide: 4-chloronicotinic acid (10.00 g, 63.47 mmol) was mixed with SOCl2 (46.30 mL, 634.7 mmol) and heated and refluxed for 4 hours. Upon completion of the reaction, excess SOCl2 was removed by rotary evaporation. toluene (25 mL) was added to the residue and toluene was again removed by rotary evaporation. The resulting oily product was slowly poured into pre-cooled 25 mL of concentrated NH4OH (0 °C). After precipitating the solid, the product was collected by filtration to give 2.7 g of 4-chloronicotinamide in 27.6% yield.
References
[1] Patent: US2007/49603, 2007, A1. Location in patent: Page/Page column 47
4-Chloropyridine-3-carboxamideSupplier
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4-Chloropyridine-3-carboxamide(7418-70-4)Related Product Information
- 4,6-DICHLORO-NICOTINAMIDE
- N5-(3-CHLORO-4-FLUOROPHENYL)-4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- N5-(4-CHLOROPHENYL)-4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- N5-[3,5-DI(TRIFLUOROMETHYL)PHENYL]-4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- 4-CHLORO-N-(2,3-DIHYDRO-1H-INDEN-2-YL)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- AURORA KA-5030
- 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- N5-(2-CHLOROPHENYL)-4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- 2,4,5,6-TETRACHLORO-NICOTINAMIDE
- AURORA KA-6162
- N3-(2,4-DICHLOROPHENYL)-4-CHLORONICOTINAMIDE
- N5-ISOPROPYL-4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- N-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-N'-(4-FLUOROPHENYL)UREA
- 4-CHLORO-N-(2-HYDROXY-1,3-DIOXO-2,3-DIHYDRO-1H-INDEN-2-YL)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXAMIDE
- AURORA KA-5031
- AURORA KA-4988
- 5,7-DICHLORO-1,3,6-TRIPHENYL-1,2,3,4-TETRAHYDROPYRIDO[2,3-D]PYRIMIDINE-2,4-DIONE
- N-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-N'-[3,5-DI(TRIFLUOROMETHYL)PHENYL]UREA