Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Chemical Properties

Melting point:

270-271 °C

Boiling point:

376.4±32.0 °C(Predicted)

Density 

1.569

storage temp. 

Keep in dark place,Sealed in dry,2-8°C

solubility 

H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)

form 

Powder

pka

2.06±0.40(Predicted)

color 

White to off-white

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Usage And Synthesis

Uses

Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).

Uses

LY 354740 is a highly selective and potent agonist of group II mGluR.

Definition

ChEBI: Eglumetad is a L-alpha-amino acid.

Biological Activity

Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.

storage

+4°C

Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)(176199-48-7)Related Product Information

• DL-ALPHA-AMINOPIMELIC ACID
• Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
• L-Cyclopropylglycine
• L-2-Aminoadipic acid
• (S)-1-CYCLOPROPYLETHYLAMINE
• Cycloleucine
• (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE
• DL-2-METHYLGLUTAMIC ACID
• 1-Amino-1-cyclohexanecarboxylic acid
• AMINO-CYCLOPROPYL-ACETIC ACID
• DL-ALPHA-AMINOSUBERIC ACID
• D-ALPHA-AMINOSUBERIC ACID
• H-ALPHA-ME-LEU-OH
• CHEMBRDG-BB 6156098
• cis-1,3-cyclohexanedicarboxylic acid
• 1-AMINO-3-METHYLCYCLOHEXANECARBOXYLIC ACID
• TALAGLUMETAD
• 2-AMINO-2-CYCLOPROPYLPROPIONIC ACID