Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Basic information
- Product Name:
- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
- Synonyms:
-
- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
- Eglumegad
- Eglumetad
- LY 354740
- (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
- Bicyclo[3.1.0]hexane-2,6-dicarboxylicacid, 2-aMino-, [1S-(1a,2b,5a,6a)]-
- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,2-amino-,(1S,2S,5R,6S)-
- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S...
- CAS:
- 176199-48-7
- MF:
- C8H11NO4
- MW:
- 185.18
- Product Categories:
-
- CYCLOPENTANE
- Glutamate
- Mol File:
- 176199-48-7.mol
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Chemical Properties
- Melting point:
- 270-271 °C
- Boiling point:
- 376.4±32.0 °C(Predicted)
- Density
- 1.569
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- H2O : 6.33 mg/mL (34.18 mM; Need ultrasonic and warming)
- form
- Powder
- pka
- 2.06±0.40(Predicted)
- color
- White to off-white
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI) Usage And Synthesis
Uses
Treatment ofgeneral anxiety disorders and smoking cessation (metabotropic glutamate agonist).
Uses
LY 354740 is a highly selective and potent agonist of group II mGluR.
Definition
ChEBI: Eglumetad is a L-alpha-amino acid.
Biological Activity
Highly selective and potent agonist of group II mGlu receptors (EC 50 values are 5.1 and 24.3 nM at mGlu 2 and mGlu 3 receptors respectively and > 100000 nM at mGlu 4 , mGlu 7 , mGlu 1a and mGlu 5a receptors). Displays antianxiety and antiaddictive activity in vivo . Orally and systemically active.
in vivo
Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) has no effect on spatial working memory performance in Gria1 / or WT mice, and it has no effect on rewarded alternation testing with a short inter-trial interval in Gria1 / and WT mice at concentration of 30 mg/kg. Eglumegad (LY354740) (15 or 30 mg/kg, i.p.) reduces spontaneous locomotor activity in wild-type and Gria1 / mice[1]. Eglumegad (LY354740) (15 mg/kg, i.p.) dreases novelty-induced hyperlocomotion in naive GluA1-KO and pre-handled GluA1-KO males, but not in females. Eglumegad (LY354740) (15 mg/kg, i.p.) significantly reduces the increased c-Fos expression of GluA1-KO males to the level of WT males, but not in of females[3]. Eglumegad (LY354740) (10 mg/kg, i.p.) attenuates the immobilization stress-induced increase in BDNF mRNA expression in the rat mPFC[4].
IC 50
mGluR2R: 5 nM (IC50); mGluR3R: 24 nM (IC50)
storage
+4°C
Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)Supplier
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Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)(176199-48-7)Related Product Information
- DL-ALPHA-AMINOPIMELIC ACID
- Bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, 2-amino-, (1S,2S,5R,6S)- (9CI)
- L-Cyclopropylglycine
- L-2-Aminoadipic acid
- (S)-1-CYCLOPROPYLETHYLAMINE
- Cycloleucine
- (2S,1'S,2'S)-2-(CARBOXYCYCLOPROPYL)GLYCINE
- DL-2-METHYLGLUTAMIC ACID
- 1-Amino-1-cyclohexanecarboxylic acid
- AMINO-CYCLOPROPYL-ACETIC ACID
- DL-ALPHA-AMINOSUBERIC ACID
- D-ALPHA-AMINOSUBERIC ACID
- H-ALPHA-ME-LEU-OH
- CHEMBRDG-BB 6156098
- cis-1,3-cyclohexanedicarboxylic acid
- 1-AMINO-3-METHYLCYCLOHEXANECARBOXYLIC ACID
- TALAGLUMETAD
- 2-AMINO-2-CYCLOPROPYLPROPIONIC ACID