Ethanone, 1-(6-quinoxalinyl)- (9CI) Chemical Properties

Melting point:

106-108 °C(Solv: cyclohexane (110-82-7))

Boiling point:

318.9±22.0 °C(Predicted)

Density 

1.216±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

-0.34±0.30(Predicted)

Appearance

Off-white to pink Solid

Ethanone, 1-(6-quinoxalinyl)- (9CI) Usage And Synthesis

Synthesis

Methylmagnesium bromide (2 mL, 3.0 mol/L, 6 mmol) was added slowly and dropwise to an anhydrous tetrahydrofuran (10 mL) solution of quinoxaline-6-carboxylic acid methoxy-methyl-amide (1 g, 4.6 mmol) at 0°C and under nitrogen protection. The reaction solution was gradually warmed to room temperature over 2 hours. Upon completion of the reaction, the reaction was quenched with ammonium chloride solution and extracted with ethyl acetate. The organic phases were combined and concentrated to give the crude product. The crude product was purified by silica gel column chromatography to afford 1-(quinoxalin-6-yl)ethanone (600 mg, 75.7% yield).

References

[1] Patent: WO2016/77232, 2016, A2. Location in patent: Page/Page column 25; 33; 35; 37
[2] Patent: WO2007/16525, 2007, A2. Location in patent: Page/Page column 99-101

Ethanone, 1-(6-quinoxalinyl)- (9CI)(83570-42-7)Related Product Information

• Ethanone, 1-(6-amino-3-pyridinyl)-
• 2-Amino-5-Acetylpyridine
• Ethanone, 1-(4-amino-3-hydroxyphenyl)- (9CI)
• 2-Chloro-5-acetylpyridine