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Miltrione

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Miltrione Basic information

Product Name:
Miltrione
Synonyms:
  • 5,6,7,8-Tetrahydro-2-isopropyl-8,8-diMethyl-3,4-phenanthrenedione
  • 5,6,7,8-Tetrahydro-8,8-diMethyl-2-(1-Methylethyl)-3,4-phenanthrenedione
  • 2-Isopropyl-5,6,7,8-tetrahydro-8,8-dimethylphenanthrene-3,4-dione
  • 5,6,7,8-Tetrahydro-8,8-dimethyl-2-isopropyl-3,4-phenanthrenedione
  • Rosmariquinone
  • C13715
  • Miltiron
  • NSC 639662
CAS:
27210-57-7
MF:
C19H22O2
MW:
282.38
Product Categories:
  • Miscellaneous Natural Products
  • Aromatics
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
27210-57-7.mol
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Miltrione Chemical Properties

Melting point:
98-100℃ (hexane )
Boiling point:
421.6±45.0 °C(Predicted)
Density 
1.094±0.06 g/cm3 (20 ºC 760 Torr)
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
powder
color 
Red
LogP
4.916 (est)
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Miltrione Usage And Synthesis

Chemical Properties

Orange granular crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Salvia miltiorrhiza.

Uses

An active component in Salvia miltiorrhiza that has been shown to inhibit the increase in the abundance of the mRNA for the α4 subunit of the GABAA receptor induced by ethanol withdrawal in cultured hippocampal neurons. A potential phytotherapeutic agent in the treatment of alcohol dependence.

Definition

ChEBI: Miltirone is an abietane diterpenoid.

in vivo

Miltirone (10-60 mg/kg, p.o.; one hour before test) increases the number of punished crossings in the four-plate test in mice[1].

Animal Model:Mice[1]
Dosage:10, 30, 60 mg/kg
Administration:Oral gavage (p.o.); an hour before test
Result:Increased the number of punished crossings of mice in the 'Four-Plate Test'.
Showed some reversal of the effect of diazepam as expected for a partial agonist.
Produced no muscle relaxant effect and did not impair the performance of mice in the Julou-Courvoisier horizontal wire test.

IC 50

CES2: 0.04 μM (Ki)

MiltrioneSupplier

J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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jkinfo@jkchemical.com
Chemsky（shanghai）International Co.,Ltd.
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021-50135380
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shchemsky@sina.com
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
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cwb1@biopurify.cn
Shanghai Winherb Medical Technology Co., Ltd.
Tel
021-38218169 13341702378
Email
winherb@126.com
The future of Shanghai Industrial Co., Ltd.
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021-61552785
Email
sales@shshiji.com
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