(-)-Bicucullinemethiodide
(-)-Bicucullinemethiodide Basic information
- Product Name:
- (-)-Bicucullinemethiodide
- Synonyms:
-
- [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
- 1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-
- 1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-
- (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
- (-)-Bicuculline methiodide
- (-)-Bicuculline methiodide DISCONTINUED. offer B382505
- ( ) Bicuculline methiodide,()Bicuculline methiodide
- (5S)-6,6-Dimethyl-5-{12-oxo-3,5,11-trioxatricyclo[7.3.0.02,]dodeca-1(9),2(6),7-trien-10-yl}-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide
- CAS:
- 40709-69-1
- MF:
- C21H20INO6
- MW:
- 0
- Product Categories:
-
- GABA/Glycine receptor
- Mol File:
- 40709-69-1.mol
(-)-Bicucullinemethiodide Chemical Properties
- RTECS
- JI4904100
- storage temp.
- Store at RT
- solubility
- H2O: soluble10mg/mL, almost clear, greenish-yellow
- form
- Pale yellow solid.
- color
- Yellow
- optical activity
- [α]/D -117±7°, c = 1 in chloroform
- BRN
- 5419649
(-)-Bicucullinemethiodide Usage And Synthesis
Uses
1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).
General Description
Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).
Biological Activity
Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.
Biochem/physiol Actions
(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.
storage
Room temperature
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