Basic information Safety Supplier Related

(-)-Bicucullinemethiodide

Basic information Safety Supplier Related

(-)-Bicucullinemethiodide Basic information

Product Name:
(-)-Bicucullinemethiodide
Synonyms:
  • [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
  • 1,3-Dioxolo(4,5-G)isoquinolinium, 5-((6R)-6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (5S)-
  • 1,3-Dioxolo(4,5-G)isoquinolinium, 5-(6,8-dihydro-8-oxofuro(3,4-E)-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-, iodide, (R-(R*,S*))-
  • (5S)-5-[(6R)-6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl]-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium iodide
  • (-)-Bicuculline methiodide
  • (-)-Bicuculline methiodide DISCONTINUED. offer B382505
  • ( ) Bicuculline methiodide,()Bicuculline methiodide
  • (5S)-6,6-Dimethyl-5-{12-oxo-3,5,11-trioxatricyclo[7.3.0.02,]dodeca-1(9),2(6),7-trien-10-yl}-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinolin-6-ium iodide
CAS:
40709-69-1
MF:
C21H20INO6
MW:
0
Product Categories:
  • GABA/Glycine receptor
Mol File:
40709-69-1.mol
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(-)-Bicucullinemethiodide Chemical Properties

RTECS 
JI4904100
storage temp. 
Store at RT
solubility 
H2O: soluble10mg/mL, almost clear, greenish-yellow
form 
Pale yellow solid.
color 
Yellow
optical activity
[α]/D -117±7°, c = 1 in chloroform
BRN 
5419649
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Safety Information

WGK Germany 
3
HazardClass 
6.1
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(-)-Bicucullinemethiodide Usage And Synthesis

Uses

1(S),9(R)-(-)-Bicuculline methiodide has been used as a gamma-aminobutyric acid (GABA) antagonist to block inhibition in the semicoronal slices. It has also been used for the preparation of organotypic hippocampal slice cultures (OHSCs).

General Description

Bicuculline is a phthalide isoquinoline alkaloid, which is extracted from Dicentra cucullaria. It acts as an acetylcholinesterase?inhibitor. Bicuculline inhibits slow afterhyperpolarization (AHP).

Biological Activity

Methiodide form of classical GABA A receptor antagonist (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). More water-soluble and stable. Non-GABA receptor-mediated actions reported, including actions on calcium-dependent potassium channels.

Biochem/physiol Actions

(-)-Bicuculline methiodide is a GABAA receptor antagonist, which acts as a competitive inhibitor of GABA ligand binding to the receptor.

storage

Room temperature

(-)-BicucullinemethiodideSupplier

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