2-HYDROXY-3-AMINO-5-PICOLINE Chemical Properties

Melting point:

119-120℃

Boiling point:

337℃

Density 

1.137

Flash point:

158℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.28±0.10(Predicted)

Safety Information

HS Code 

2933399990

2-HYDROXY-3-AMINO-5-PICOLINE Usage And Synthesis

Synthesis

Example 102A. Synthesis of 3-amino-5-methylpyridin-2-ol: 5-methyl-3-nitropyridin-2-ol (50 mg, 0.32 mmol) was dissolved in methanol (5 mL) and ammonium chloride (174 mg, 3.24 mmol) and zinc powder (106 mg, 1.62 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 1 h, during which a color change was observed. After completion of the reaction, the suspension was removed by filtration and the filter cake was washed with methanol. The filtrates were combined and concentrated under reduced pressure to remove the solvent. The crude product was purified by grinding with a solvent mixture of methanol and ethyl acetate (1:1, v/v). After filtration, the solvent was removed under reduced pressure to afford the target compound 3-amino-5-methylpyridin-2-ol (16 mg, 0.13 mmol, 40% yield). The product was characterized by NMR hydrogen spectroscopy (400 MHz, MeOD): δ 2.03 (s, 3H), 6.56 (s, 1H), 6.63 (s, 1H).

References

[1] Patent: WO2014/22343, 2014, A1. Location in patent: Paragraph 00265
[2] Journal of the American Chemical Society, 1950, vol. 72, p. 2806
[3] Journal of the American Chemical Society, 1957, vol. 79, p. 3552
[4] Patent: EP2471792, 2012, A1. Location in patent: Page/Page column 43

2-HYDROXY-3-AMINO-5-PICOLINE(52334-51-7)Related Product Information

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• 2-HYDROXY-3-AMINO-5-PICOLINE
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