3-Hydroxy-2-iodo-6-methylpyridine Chemical Properties

Melting point:

197-199 °C (lit.)

Boiling point:

292.0±35.0 °C(Predicted)

Density 

1.8615 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

pka

5.46±0.10(Predicted)

Appearance

White to light brown Solid

InChI

InChI=1S/C6H6INO/c1-4-2-3-5(9)6(7)8-4/h2-3,9H,1H3

InChIKey

HRZOWBGCOJWHDY-UHFFFAOYSA-N

SMILES

C1(I)=NC(C)=CC=C1O

CAS DataBase Reference

23003-30-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25

WGK Germany 

3

HS Code 

29333999

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

3-Hydroxy-2-iodo-6-methylpyridine Usage And Synthesis

Chemical Properties

Light yellow to yellow powder

Synthesis

Step A: 6-Methylpyridin-3-ol (0.5 g, 4.58 mmol) was dissolved in aqueous sodium hydroxide solution (4.5 mL, 1 M, 4.5 mmol). Iodine (1.28 g, 5.2 mmol) was added to this solution and the reaction mixture was stirred overnight at room temperature. After completion of the reaction, it was neutralized with aqueous hydrochloric acid (2 M) to pH ≈ 7. A white precipitate precipitated from the reaction system and the product was collected by filtration. The solid product was washed with deionized water and dried to give 2-iodo-6-methylpyridin-3-ol (0.8 g, 50% yield). Mass spectral analysis showed m/z 236.0 [M + H]+.

References

[1] Bioorganic and Medicinal Chemistry Letters, 1998, vol. 8, # 16, p. 2117 - 2122
[2] Patent: US9617268, 2017, B2. Location in patent: Page/Page column 400; 401
[3] Patent: EP1477186, 2004, A1. Location in patent: Page/Page column 35; 36
[4] Patent: EP1357111, 2003, A1. Location in patent: Page/Page column 54
[5] Tetrahedron, 2007, vol. 63, # 13, p. 2787 - 2797

3-Hydroxy-2-iodo-6-methylpyridine(23003-30-7)Related Product Information

• 4-Methylpyridine
• Methyl acetate
• 2-Chloro-3-hydroxypyridine
• 2,6-Lutidine
• 3-Hydroxypyridine
• Azamethiphos
• Bensulfuron methyl
• Methylparaben
• CHLOROPHOSPHONAZO III
• Methyl acrylate
• METSULFURON METHYL
• Kresoxim-methyl
• 2,4,6-Collidine
• Thiophanate-methyl
• Methyl
• Parathion-methyl
• 4-IODO-PYRIDIN-3-OL
• Ammonium iodide