LADOSTIGIL
LADOSTIGIL Basic information
- Product Name:
- LADOSTIGIL
- Synonyms:
-
- LADOSTIGIL
- Ladostigil (TV-3,326)
- LHXOCOHMBFOVJS-OAHLLOKOSA-N
- Carbamic acid, N-ethyl-N-methyl-, (3R)-2,3-dihydro-3-(2-propyn-1-ylamino)-1H-inden-5-yl ester
- TV-3326|||Ladostigil|||TV 3326|||TV3326|||Ladostigil free base
- Ladostigil, 10 mM in DMSO
- CAS:
- 209394-27-4
- MF:
- C16H20N2O2
- MW:
- 272.34
- Mol File:
- 209394-27-4.mol
More
Less
LADOSTIGIL Chemical Properties
- Boiling point:
- 412.4±45.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- pka
- 6.94±0.20(Predicted)
More
Less
LADOSTIGIL Usage And Synthesis
Uses
Treatment of Alzheimer’s disease (an inhibitor of monoamine oxidase (MAO-A and B), an acetylcholinesterase inhibitor, and a neuroprotectant).
Definition
ChEBI: Ladostigil is a member of indanes.
in vivo
Ladostigil (17 mg/kg; p.o. daily for 6 weeks) abolishes their hyperanxiety and depressive-like behaviour in the elevated plus maze (EPM) and forced swim tests (FST) tests in adulthood from puberty to prenatally-stressed rats[4].
Ladostigil (50 μmol/kg; single p.o.) restores the loss of episodic memory in the object recognition test in rats[3].
| Animal Model: | Pathogen-free (SPF) Sprague-Dawley rats[4] |
| Dosage: | 17 mg/kg |
| Administration: | P.o. (added to the drinking water) daily for 6 weeks |
| Result: | Inhibited brain MAO-A and B by more than 60%. Reduced hyperanxiety of male and female prenatally stressed (PS) rats in the EPM and depressive-like behaviour in the FST. |
IC 50
MAO-B: 37.1 μM (IC50); AChE: 31.8 μM (IC50)
LADOSTIGILSupplier
LGM Pharma
- Tel
- 1-(800)-881-8210
- inquiries@lgmpharma.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com
BOC Sciences
- Tel
- info@bocsci.com
Beijing Jin Ming Biotechnology Co., Ltd.
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
TargetMol Chemicals Inc.
- Tel
- 4008200310
- marketing@tsbiochem.com