4-Bromo-2-fluorophenylacetic acid Chemical Properties

Melting point:

123-126°

Boiling point:

320.4±27.0 °C(Predicted)

Density 

1.697±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

3.89±0.10(Predicted)

form 

Solid

Appearance

White to off-white Solid

InChI

InChI=1S/C8H6BrFO2/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2,(H,11,12)

InChIKey

PNBIYFPZODYMOO-UHFFFAOYSA-N

SMILES

C1(CC(O)=O)=CC=C(Br)C=C1F

Safety Information

Hazard Codes 

Xi

HS Code 

2916399090

4-Bromo-2-fluorophenylacetic acid Usage And Synthesis

Uses

4-Bromo-2-fluorophenylacetic acid is a carboxylic acid organic compound, which can be used as a pharmaceutical intermediate for pharmaceutical synthesis and scientific research.

Synthesis

4-Bromo-2-fluorophenylacetic acid can be prepared by reacting 2-(4-bromo-2-fluorophenyl)acetonitrile with MeOH in NaOH solution.

References

[1] Patent: US5827863, 1998, A
[2] Patent: US2014/275111, 2014, A1. Location in patent: Paragraph 0232; 0235; 0236
[3] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 44; 54; 57
[4] Patent: WO2011/45703, 2011, A2. Location in patent: Page/Page column 44-45
[5] Patent: WO2016/38519, 2016, A1. Location in patent: Page/Page column 36

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