3-Bromo-4-hydroxypyridine Chemical Properties

Melting point:

225-230℃

Boiling point:

338.2±22.0 °C(Predicted)

Density 

1.788±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Room Temperature

form 

powder

pka

3.71±0.18(Predicted)

color 

light yellow

CAS DataBase Reference

36953-41-0(CAS DataBase Reference)

Safety Information

HS Code 

2933399990

3-Bromo-4-hydroxypyridine Usage And Synthesis

Uses

3-Bromo-4-hydroxypyridine is a pyrrole that can be used in cancer treatment. It inhibits the growth of cancer cells by binding to MKN-45 on the cell surface, thereby preventing it from binding to other proteins and triggering cell proliferation.

Synthesis

3-Bromo-4-hydroxypyridine is synthesized from 3-bromo-5 hydroxypyridine by reacting it with ammonia or methylamine.
Concentrated sulfuric acid (85.0mL) and the 3-bromo-4-aminopyridine (113.0g, 0.65mol) were added successively to the distilled water (550.0mL) at 0°C, and then NaNO2 (63.1g, 0.91mol) aqueous solution (130.0mL) was added drop-wise to maintain the temperature between 0 and 5°C. After stirring at r. t. for 1h, the reaction mixture was heated at 95°C for a further 0.5h. Upon cooling to below 0°C, the mixture was alkalized to pH 6 with saturated sodium hydroxide solution, washed with ethyl acetate (200mL×3) and brine (200mL), dried over anhydrous Na2SO4, filtered and concentrated to yield 3-Bromo-4-hydroxypyridine as a yellow solid (75.1g, 66.2percent).

3-Bromo-4-hydroxypyridine(36953-41-0)Related Product Information

• 1-Hexadecylpyridinium bromide
• 3-Aminopyridine
• 3-Hydroxypyridine
• 4-Hydroxypyridine
• 3-Bromoanisole
• 3-BROMO-4-FLUOROPYRIDINE
• 2-Chloro-3-cyanopyridine
• 3-BROMO-4-METHOXY-PYRIDINE
• Bromine
• 3-BROMO-5-HYDROXYPYRIDINE,5-BROMO-3-HYDROXYPYRIDINE
• 4-BROMO-2-HYDROXYPYRIDINE
• 3-BROMO-2-HYDROXYPYRIDINE
• METHYL 5-BROMO-2-HYDROXYPYRIDINE-3-CARBOXYLATE
• 3,5-DIBROMO-2-HYDROXYPYRIDINE
• 4-BROMO-3-HYDROXYPYRIDINE
• Methyl 5-Bromo-2-hydroxypyridine-4-carboxylate, 5-Bromo-4-methoxycarbonyl-2(1H)-pyridinone
• 5-BROMO-6-HYDROXYPYRIDINE-3-CARBOXYLIC ACID
• 2-Bromo-4-Hydroxypyridine