Indanidine
Indanidine Basic information
- Product Name:
- Indanidine
- Synonyms:
-
- Indanidine
- N-(2-Imidazolin-2-yl)-2-methyl-2H-indazol-4-amine
- N-(4,5-Dihydro-1H-imidazol-2-yl)-2-methyl-2H-indazol-4-amine
- 2H-Imidazole, 4-(2-imidazolin-2-ylamino)-2-methyl-
- 4-(2-Imidazolin-2-ylamino)-2-methyl-2H-imidazole
- Indanidine [inn]
- Indanidinum
- Unii-mp564ife34
- CAS:
- 85392-79-6
- MF:
- C11H13N5
- MW:
- 215.25
- Mol File:
- 85392-79-6.mol
Indanidine Chemical Properties
- Boiling point:
- 413.3±37.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 8.83±0.10(Predicted)
- color
- White to off-white
Indanidine Usage And Synthesis
Uses
Indanidine is an alpha-adrenergic agonist.
in vivo
The selective alpha 1-adrenoceptor agonist, Indanidine, also behaved as a partial agonist in the aorta and produced no significant contractions of the small mesenteric artery. Since Idazoxan and Indanidine have been reported to raise blood pressure in the pithed rat via an action at vascular alpha 1-adrenoceptors, these results call into question the reliability of the small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity in vivo[1].
References
[1] Van der Graaf PH, et al. Analysis of the action of idazoxan calls into question the reliability of the rat isolated small mesenteric artery assay as a predictor for alpha 1-adrenoceptor-mediated pressor activity. Naunyn Schmiedebergs Arch Pharmacol. 1996 DOI:10.1007/BF00171074
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