Chlorohydroquinone Chemical Properties

Melting point:

100-104 °C (lit.)

Boiling point:

263 °C (lit.)

Density 

1.2558 (rough estimate)

refractive index 

1.4620 (estimate)

Flash point:

263°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

pka

9.21±0.18(Predicted)

form 

Fine Crystalline Powder

color 

Light brown to gray

Water Solubility 

soluble

BRN 

636835

CAS DataBase Reference

615-67-8(CAS DataBase Reference)

NIST Chemistry Reference

1,4-Benzenediol, 2-chloro-(615-67-8)

EPA Substance Registry System

Chlorohydroquinone (615-67-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

21-36/37/38-43

Safety Statements 

36/37-37/39-26

RIDADR 

UN2811

WGK Germany 

3

RTECS 

MX4800000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

III

HS Code 

29081990

Hazardous Substances Data

615-67-8(Hazardous Substances Data)

Toxicity

An antidiarrhea drug used extensively in Japan. It has been shown to be the cause of subacute myelooptic neuropathy, a syndrome in which stiffness of the joints is accompanied by damage to the optic nerve.

MSDS

• Language:English Provider:2-Chloro-1,4-dihydroxybenzene
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Chlorohydroquinone Usage And Synthesis

Chemical Properties

light brown to grey fine crystalline powder. It precipitates leafy crystals from chloroform and needle-like crystals from toluene. Freely soluble in water and alcohol, slightly soluble in ether and hot chloroform.

Uses

Chlorohydroquinone is a component of polyethers based on organotin with potential application to breast cancer treatment via growth inhibition. Also a component in the synthesis of contraceptive agents in pharmaceutical compounds. It is also used within hydroxylation and catalysis organic reactions in the synthesis of pharmacologically active phenolic compounds.

Preparation

Chlorohydroquinone is obtained by reacting p-benzoquinone with hydrochloric acid. First dissolve p-benzoquinone with chloroform and pass dry hydrogen chloride gas under cooling to obtain.

Application

Chlorohydroquinone is a benzenediol that consists of hydroquinone bearing a single chloro substituent. It has a role as a metabolite. It is a member of monochlorobenzenes and a member of chlorohydroquinones. Chlorohydroquinone is used in photographic developing solutions. It is also a bactericide.

Definition

ChEBI: Chlorohydroquinone is a benzenediol that consists of hydroquinone bearing a single chloro substituent. It has a role as a metabolite. It is a member of monochlorobenzenes and a member of chlorohydroquinones.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by skin contact. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl-. See also CHLORIDES.

Purification Methods

Crystallise the hydroquinone from CHCl3 or toluene. [Beilstein 6 IV 5767.]

Chlorohydroquinone(615-67-8)Related Product Information

• tert-Butylhydroquinone
• Trimethylhydroquinone
• Triclosan
• Hydroquinone
• 4-Hydroxybenzoic acid
• VITAMIN K4
• 2-Methylhydroquinone
• 4-Hydroxybenzaldehyde
• 4-Cyanophenol
• 4-tert-Butylcatechol
• Diphenyl chlorophosphate
• Methylparaben
• Resorcinol
• Catechol
• NAPHTHOL AS-LC ACETATE
• Naphthol AS-LC
• 1-CHLORO-2,5-DIETHOXYBENZENE
• TETRACHLOROHYDROQUINONE