1-BROMO-2,4,6-TRIMETHOXYBENZENE Chemical Properties

Melting point:

97-99°C

Boiling point:

303.5±37.0 °C(Predicted)

Density 

1.391±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

solid

color 

White

InChI

InChI=1S/C9H11BrO3/c1-11-6-4-7(12-2)9(10)8(5-6)13-3/h4-5H,1-3H3

InChIKey

BPWYNWSOQOXOPI-UHFFFAOYSA-N

SMILES

C1(OC)=CC(OC)=CC(OC)=C1Br

CAS DataBase Reference

1131-40-4(CAS DataBase Reference)

EPA Substance Registry System

2-Bromo-1,3,5-trimethoxybenzene (1131-40-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22

Safety Statements 

22-36/37/39

Hazard Note 

Irritant

HS Code 

29093090

1-BROMO-2,4,6-TRIMETHOXYBENZENE Usage And Synthesis

Synthesis

General procedure for the synthesis of 1-bromo-2,4,6-trimethoxybenzene from 2,4,6-trimethoxybenzoic acid: a mixture of 2,4,6-trimethoxybenzoic acid (1 eq., 0.5 mmol), CuBr2 or CuCl2 (2 eq., 1 mmol), Ag2CO3 (1 eq., 0.5 mmol), and PdCl2 (0.1 eq.) was dissolved in THF (3 mL) and the reaction was refluxed at 110 °C for 24 hours. Upon completion of the reaction, the reaction mixture was concentrated under reduced pressure and purified by column chromatography to afford the target product 1-bromo-2,4,6-trimethoxybenzene.

References

[1] Tetrahedron Letters, 2013, vol. 54, # 24, p. 3079 - 3081
[2] Journal of Organic Chemistry, 2016, vol. 81, # 7, p. 2794 - 2803

1-BROMO-2,4,6-TRIMETHOXYBENZENE(1131-40-4)Related Product Information

• 1-Bromo-3,4,5-trimethoxybenzene
• 2-BROMO-5-METHOXYPHENOL
• 2-Bromoanisole
• 4-Bromoresorcinol
• 4-Bromo-3-methoxyphenol
• 2-Bromoresorcinol
• 1-BROMO-2,6-DIMETHOXYBENZENE
• 1-Bromo-2,4-dimethoxybenzene
• 8-BROMO-5,7-DIMETHOXY-2-METHYLCHROMANE
• 8-BROMO-5,7-DIMETHOXY-CHROMEN-2-ONE
• 2-BROMO-3-METHOXYPHENOL
• 1-BROMO-2,4,6-TRIMETHOXYBENZENE