Basic information Safety Supplier Related

2-Hydroxymethyl Loratadine

Basic information Safety Supplier Related

2-Hydroxymethyl Loratadine Basic information

Product Name:
2-Hydroxymethyl Loratadine
Synonyms:
  • Loratadine 2-Hydroxymethyl Impurity (USP)
  • 2-Hydroxymethyl Loratadine
  • 4-[8-Chloro-5,6-dihydro-2-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic Acid Ethyl Este
  • 4-[8-Chloro-5,6-dihydro-2-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidinecarboxylic Acid Ethyl Ester
  • Ethyl 4-[8-chloro-5,6-dihydro-2-(hydroxy methyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-1-piperidine carboxylate
  • Loratadine Impurity 2
  • Loratadine Impurity 25
  • 1-Piperidinecarboxylic acid, 4-[8-chloro-5,6-dihydro-2-(hydroxymethyl)-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene]-, ethyl ester
CAS:
609806-39-5
MF:
C23H25ClN2O3
MW:
412.91
Product Categories:
  • Metabolites & Impurities
  • Pharmaceuticals
  • Intermediates & Fine Chemicals
Mol File:
609806-39-5.mol
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2-Hydroxymethyl Loratadine Chemical Properties

Melting point:
76-78°C
Boiling point:
585.5±50.0 °C(Predicted)
Density 
1.301±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
pka
13.40±0.10(Predicted)
color 
White to Off-White
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2-Hydroxymethyl Loratadine Usage And Synthesis

Chemical Properties

White Solid

Uses

A usual impurity in Loratadine syrup formulations, a nonsedating-type histamine H1-receptor. Loratadine 2-Hydroxymethyl Impurity (USP).

Definition

ChEBI: 2-Hydroxymethyl Loratadine is a benzocycloheptapyridine.

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