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Ambamustine

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Ambamustine Basic information

Product Name:
Ambamustine
Synonyms:
  • Ambamustine [inn]
  • N-(3-(m-(Bis(2-chloroethyl)amino)phenyl)-N-(3-(p-fluorophenyl)-L-alanyl)-L-alanyl)-L-methionine, ethyl ester
  • Unii-ib1H345F24
  • Ambamustine
  • L-Methionine, 4-fluoro-L-phenylalanyl-3-[bis(2-chloroethyl)amino]-L-phenylalanyl-, ethyl ester
  • Ambamustine USP/EP/BP
CAS:
85754-59-2
MF:
C29H39Cl2FN4O4S
MW:
629.621
Mol File:
85754-59-2.mol
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Ambamustine Usage And Synthesis

Uses

Ambamustine (PTT119) is a new bifunctional alkylating agent and induces DNA damage by alkylating mechanisms. Ambamustine interferes with late steps in murine mammary tumor virus (MuMTV) processing and maturation and reduces production of the B-type retrovirus MuMTV. Ambamustine possesses cytolytic and antiviral activities[1][2].

References

[1] M J Yagi, et al. Interference of mouse mammary tumor virus replication by PTT.119 [p-fluoro-L-phe-m-bis-(2-chloroethyl)amino-L-phe-met ethoxy HCl]--an antitumor agent. J Natl Cancer Inst. 1986 Mar;76(3):493-501. PMID:3005743
[2] A Ardizzoni, et al. Ambamustine in the second-line treatment of patients with small-cell lung cancer: a phase II Fonicap study. Am J Clin Oncol. 2000 Feb;23(1):22-5. DOI:10.1097/00000421-200002000-00005

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LGM Pharma
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Dideu Industries Group Limited
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TargetMol Chemicals Inc.
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15002134094
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